Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50018627
TargetAlpha-synuclein(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50610486(CHEMBL5290387)
Affinity DataKd:  68nMAssay Description:Inhibition of alpha-Synuclein (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610480(CHEMBL5288110)
Affinity DataKi:  530nMAssay Description:Binding affinity to fluorescent-labeled BH3 peptide from GST tagged MCL1 (172 to 320 residues) (unknown origin) expressed in Escherichia coli BL21 (D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50610488(CHEMBL5272304)
Affinity DataKd:  700nMAssay Description:Binding affinity to amyloid beta 40 (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50610489(CHEMBL5285116)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to amyloid beta 42 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610484(CHEMBL5281638)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of fluorescent-labeled BH3 peptide from recombinant MCL1 (unknown origin) by fluorescence polarization-based competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610485(CHEMBL5276552)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of fluorescent-labeled BH3 peptide from recombinant MCL1 (unknown origin) by fluorescence polarization-based competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610494(CHEMBL5275844)
Affinity DataKi:  2.90E+3nMAssay Description:Displacement of fluorescein tagged Bak BH3 peptide from MCL-1 (172 to 327 residues) (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610492(CHEMBL5284772)
Affinity DataIC50: 3.20E+3nMAssay Description:Antagonist activity at human his 6- trx tagged MCL1-Bim BH3 peptide by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTrypanothione reductase(Leishmania infantum)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50610481(CHEMBL5282364)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli BL21 (DE3) using TS2 and NADPH as substrate by incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetIslet amyloid polypeptide(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50610487(CHEMBL5272189)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of islet amyloid polypeptide (unknown origin) aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTrypanothione reductase(Leishmania infantum)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50610482(CHEMBL5284189)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli BL21 (DE3) using TS2 and NADPH as substrate by incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610491(CHEMBL5272424)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of hypoxia-induced HIF1alpha/P300 interaction (unknown origin) incubated for 30 mins for fluorescence anisotropy competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610483(CHEMBL5275323)
Affinity DataKi:  9.30E+3nMAssay Description:Displacement of fluorescent-labeled BH3 peptide from recombinant MCL1 (unknown origin) by fluorescence polarization-based competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMyc proto-oncogene protein(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50610490(CHEMBL5286777)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to c-MYC (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610492(CHEMBL5284772)
Affinity DataIC50: 3.20E+4nMAssay Description:Antagonist activity at human his 6- trx tagged MCL1-Bim BH3 peptide by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50610493(CHEMBL5290707)
Affinity DataIC50: 7.20E+4nMAssay Description:Inhibition of FITC-labeled BH3 peptide binding to MCL1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed