Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50013552
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM47478(MLS000851064 | SMR000457307 | 2-[(4-chlorophenyl)s...)
Affinity DataIC50: 60nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM57768(SMR000299654 | 7-{(4-methoxyphenyl)[(4-methyl-2-py...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567349(CHEMBL4846043)
Affinity DataIC50: 140nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567345(CHEMBL4872913)
Affinity DataIC50: 180nMAssay Description:Inhibition of human HDAC8 using using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567345(CHEMBL4872913)
Affinity DataIC50: 180nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 expressed in Escherichia coli using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM54510(5-chloro-N-[4-[ethyl(phenyl)sulfamoyl]phenyl]-2-me...)
Affinity DataIC50: 210nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567347(CHEMBL4852477)
Affinity DataIC50: 330nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567341(CHEMBL4871087)
Affinity DataIC50: 400nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 using fluorogenic substrate by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567344(CHEMBL4868142)
Affinity DataIC50: 440nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 expressed in Escherichia coli using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567344(CHEMBL4868142)
Affinity DataIC50: 470nMAssay Description:Inhibition of human HDAC8 using using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567341(CHEMBL4871087)
Affinity DataIC50: 630nMAssay Description:Inhibition of human HDAC8 using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567342(CHEMBL4846377)
Affinity DataIC50: 750nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 using fluorogenic substrate by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50164534(CHEMBL3800287)
Affinity DataIC50: 970nMAssay Description:Inhibition of human HDAC8 using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567342(CHEMBL4846377)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of human HDAC8 using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50164534(CHEMBL3800287)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 using Fluor de Lys as substrate by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50396169(CHEMBL1337170)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567343(CHEMBL4878864)
Affinity DataIC50: 2.65E+3nMAssay Description:Inhibition of human HDAC6 using ZMAL(Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by trypsin addition and measured after 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567348(CHEMBL4858362)
Affinity DataIC50: 2.84E+3nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetThioredoxin glutathione reductase(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567346(CHEMBL4871407)
Affinity DataIC50: 3.15E+3nMAssay Description:Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 50 mins by thio-glo reagent based fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567345(CHEMBL4872913)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human HDAC6 using ZMAL(Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by trypsin addition and measured after 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50164534(CHEMBL3800287)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human HDAC6 using Z(Tfa)Lys-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567343(CHEMBL4878864)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human HDAC1 (1 to 482 reidue) expressed in sf9 cells using ZMAL(Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by tryps...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567341(CHEMBL4871087)
Affinity DataIC50: 5.12E+3nMAssay Description:Inhibition of human HDAC6 using Z-Lys(Ac)-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567343(CHEMBL4878864)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of Schistosoma mansoni HDAC8 expressed in Escherichia coli using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567342(CHEMBL4846377)
Affinity DataIC50: 7.11E+3nMAssay Description:Inhibition of human HDAC6 using Z-Lys(Ac)-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567343(CHEMBL4878864)
Affinity DataIC50: 7.69E+3nMAssay Description:Inhibition of human HDAC8 using using Fluor de Lys as substrate incubated for 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567345(CHEMBL4872913)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of human HDAC1 (1 to 482 reidue) expressed in sf9 cells using ZMAL(Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by tryps...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567344(CHEMBL4868142)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of human HDAC6 using ZMAL(Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by trypsin addition and measured after 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50567344(CHEMBL4868142)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human HDAC1 (1 to 482 reidue) expressed in sf9 cells using ZMAL(Cbz-(Ac)Lys-AMC as substrate preincubated for 90 mins followed by tryps...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetATP-diphosphohydrolase 1(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50185446(cardamonin | cardamomin | (E)-1-(2,4-dihydroxy-6-m...)
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of Schistosoma mansoni ATPDase1 preincubated for 30 mins followed by addition of ATP/ADP by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50164534(CHEMBL3800287)
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of human HDAC1 (1 to 482 reidue) expressed in sf9 cells using Fluor de Lys as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetATP-diphosphohydrolase 1(Blood fluke)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM76395((E)-1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-prop...)
Affinity DataIC50: 3.06E+4nMAssay Description:Inhibition of Schistosoma mansoni ATPDase1 incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed