Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50013699
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using Midazolam as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using Dextromethorphan as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1A2(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50028963(beta-naphthoflavone | 3-phenyl-1H-benzo[f]chromen-...)
Affinity DataIC50: 84nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50090677(CHEMBL1109 | 4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-...)
Affinity DataIC50: 367nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using Diclofenac as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568682(CHEMBL4861470)
Affinity DataIC50: 960nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568680(CHEMBL4848124)
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568685(CHEMBL4852836)
Affinity DataIC50: 3.12E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568683(CHEMBL4873065)
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568681(CHEMBL4862779)
Affinity DataIC50: 3.62E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568679(CHEMBL4855289)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568684(CHEMBL4855989)
Affinity DataIC50: 4.23E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568677(CHEMBL4856017)
Affinity DataIC50: 4.32E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568678(CHEMBL4878971)
Affinity DataIC50: 5.12E+3nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568682(CHEMBL4861470)
Affinity DataIC50: 7.76E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using Mephenytoin as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568682(CHEMBL4861470)
Affinity DataIC50: 8.91E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using Diclofenac as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-2-phenylcyclopropanamine | cid_2723716 | (...)
Affinity DataIC50: 9.25E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using Mephenytoin as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM18207(dexamethasone (tetramethyl-rhodamine conjugated ) ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568682(CHEMBL4861470)
Affinity DataIC50: 4.22E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568682(CHEMBL4861470)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using Dextromethorphan as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568682(CHEMBL4861470)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using Midazolam as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed