Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50012415
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557487(Tolebrutinib)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human BTK in human microglia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50463838(CHEMBL4238926)
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK3 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557485(Rilzabrutinib | Prn-1008 | Prn1008)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50369724(HM71224 | Ly3337641 | Poseltinib)
Affinity DataIC50: 2nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50463838(CHEMBL4238926)
Affinity DataIC50: 4nMAssay Description:Inhibition of human JAK1 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557483(CHEMBL4782814)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50463838(CHEMBL4238926)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Tyk2 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50463838(CHEMBL4238926)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557486(CHEMBL4747506)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay with pre-incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human Tyk2 expressed in sf21 baculovirus expression system assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557483(CHEMBL4782814)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human Tyk2 expressed in sf21 baculovirus expression system assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human JAK3 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557484(Elsubrutinib | ABBV-105 | ABBV105)
Affinity DataIC50: 33nMAssay Description:Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557483(CHEMBL4782814)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human JAK2 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human JAK2 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 636nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557483(CHEMBL4782814)
Affinity DataIC50: 992nMAssay Description:Inhibition of recombinant human JAK3 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human JAK2 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of recombinant human Tyk2 expressed in sf21 baculovirus expression system assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 6.49E+3nMAssay Description:Inhibition of recombinant human JAK3 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human Tyk2 expressed in sf21 baculovirus expression system assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human JAK3 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human JAK2 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed