Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50015194
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50030474(US9562012, rosiglitazone | CHEBI:50122 | Avandamet...)
Affinity DataEC50:  83nMAssay Description:Agonist activity at recombinant N-terminal His6 -tagged GFP fused PPARgamma LBD (unknown origin) (203 to 477 residues) expressed in Escherichia cell ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50583626(CHEMBL5077503)
Affinity DataEC50:  270nMAssay Description:Agonist activity at recombinant N-terminal His6 -tagged GFP fused PPARgamma LBD (unknown origin) (203 to 477 residues) expressed in Escherichia cell ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50583627(CHEMBL5075221)
Affinity DataEC50:  5.20E+3nMAssay Description:Agonist activity at recombinant N-terminal His6 -tagged GFP fused PPARgamma LBD (unknown origin) (203 to 477 residues) expressed in Escherichia cell ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50583627(CHEMBL5075221)
Affinity DataEC50:  240nMAssay Description:Inhibition of recombinant human C-terminal sEH (222 to 555 residues) expressed in Escherichia coli BL21-DE3 using PHOME as substrate assessed as redu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50144892(CHEMBL3764398)
Affinity DataEC50:  390nMAssay Description:Agonist activity at human GAL4 DBD-fused PPARgamma LBD (203 to 505 residues) transfected in HEK293T cells assessed as fold activation incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50583626(CHEMBL5077503)
Affinity DataEC50:  400nMAssay Description:Agonist activity at human GAL4 DBD-fused PPARgamma LBD (203 to 505 residues) transfected in HEK293T cells assessed as fold activation incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50583627(CHEMBL5075221)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human GAL4 DBD-fused PPARgamma LBD (203 to 505 residues) transfected in HEK293T cells assessed as fold activation incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50327809(1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluorometho...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human C-terminal sEH (222 to 555 residues) expressed in Escherichia coli BL21-DE3 using PHOME as substrate assessed as redu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional epoxide hydrolase 2(Human)
Goethe University

Curated by ChEMBL
LigandPNGBDBM50583626(CHEMBL5077503)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human C-terminal sEH (222 to 555 residues) expressed in Escherichia coli BL21-DE3 using PHOME as substrate assessed as redu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)