Compile Data Set for Download or QSAR
Report error Found 80 Enz. Inhib. hit(s) with all data for entry = 50018630
TargetStimulator of interferon genes protein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610503(CHEMBL5290385)
Affinity DataEC50:  130nMAssay Description:Agonist activity at STING in human THP1-Dual cells assessed as increase in IFN-beta secretion incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610497(CHEMBL5281082)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human TLR7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human TLR7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at human TLR7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50440284(CHEMBL2424780 | US9708325, GS-9620 | US10457681, C...)
Affinity DataEC50:  291nMAssay Description:Agonist activity at human TLR7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  4.50E+3nMAssay Description:Agonist activity at human TLR8 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610498(CHEMBL5290445)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TLR8 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50440284(CHEMBL2424780 | US9708325, GS-9620 | US10457681, C...)
Affinity DataEC50:  9.00E+3nMAssay Description:Agonist activity at human TLR8 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610499(CHEMBL5287243)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to human STING assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610500(CHEMBL5280499)
Affinity DataKd:  4nMAssay Description:Binding affinity to human STING assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610501(CHEMBL5276324)
Affinity DataKd:  1.04E+3nMAssay Description:Binding affinity to human STING assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610502(CHEMBL166512)
Affinity DataKd:  130nMAssay Description:Agonist activity at mouse STINGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50214969(Mangostin | alpha-mangostin | 1,3,6-Trihydroxy-7-m...)
Affinity DataKd:  1.37E+5nMAssay Description:Binding affinity to human STING assessed as dissociation constant by surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50546219(CHEMBL4752026 | US11596633, Compound B | US1170239...)
Affinity DataIC50: 0.0583nMAssay Description:Inhibition of wildtype SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610507(CHEMBL5271975)
Affinity DataIC50: 0.100nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM249900(US9447106, 27 | US9556188, Compound 27 | US1000578...)
Affinity DataIC50: 0.300nMAssay Description:Irreversible inhibition of recombinant human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 0.318nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 0.335nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Irreversible inhibition of recombinant human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US9987276, Compou...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610505(CHEMBL5290606)
Affinity DataIC50: 0.5nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50: 0.850nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50: 1nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610504(CHEMBL3892767)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50239946(CHEMBL4084368)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PD-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610506(CHEMBL5269771)
Affinity DataIC50: 2.90nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US9758524, Example 6 | U...)
Affinity DataIC50: 3nMAssay Description:Irreversible inhibition of recombinant human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610508(CHEMBL5273455)
Affinity DataIC50: 4nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetArginase-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 5nMAssay Description:Binding affinity to human ARG1 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50369719(CHEMBL4162057)
Affinity DataIC50: 5.90nMAssay Description:Reversible inhibition of human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610520(CHEMBL5268100)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of SHP2 (unknown origin) E76K mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetArginase-2, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 8.5nMAssay Description:Binding affinity to human ARG2 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM291522(US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610520(CHEMBL5268100)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of wildtype SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of SHP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransforming growth factor beta-1 proprotein(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50015639(CHEMBL3260567 | USRE47141, Example 2)
Affinity DataIC50: 13nMAssay Description:Inhibition of TGF-beta receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 14nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610514(CHEMBL5276767)
Affinity DataIC50: 15nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50: 16nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50: 18nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50: 19nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610519(CHEMBL5269504)
Affinity DataIC50: 23nMAssay Description:Inhibition of SHP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610519(CHEMBL5269504)
Affinity DataIC50: 23nMAssay Description:Inhibition of wildtype SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetArginase-2, mitochondrial(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50561034(CHEMBL4244287)
Affinity DataIC50: 30nMAssay Description:Binding affinity to human ARG2 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50610514(CHEMBL5276767)
Affinity DataIC50: 30nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
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