Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50013485
TargetCytochrome P450 2B6(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 8(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 3.51E+6nMAssay Description:Inhibition of human OAT3 assessed as reduction in OAT3-mediated tenofovir transportMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 3.86E+6nMAssay Description:Inhibition of human OAT1 assessed as reduction in OAT1-mediated tenofovir transportMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP3A5 in human liver microsomes using testosterone as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP3A5 in human liver microsomes using midazolam as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Time-dependent inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP3A5 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP3A5 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP2D6 in human liver microsomes using bufuralol as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP2C9 in human liver microsomes using diclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Hemoshear Therapeutics

Curated by ChEMBL
LigandPNGBDBM50566497(2,2-DIMETHYLBUTYRATE | CHEBI:38649 | 2,2-Dimethyl-...)
Affinity DataIC50: 1.00E+7nMAssay Description:Direct inhibition of CYP2B6 in human liver microsomes using bupropion as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed