Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50015619
TargetHistone acetyltransferase p300(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587856(CHEMBL5174658)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal His/GST-tagged recombinant human p300 HAT domain (965 to 1810 residues) expressed in Sf9 insect cells using isotope labelled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587860(CHEMBL5183944)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 10 mins by Ellman's colorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50300549(2,3-Dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 10 mins by Ellman's colorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50300549(2,3-Dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[...)
Affinity DataIC50: 9.06E+3nMAssay Description:Inhibition of human MAO-B preincubated for 30 mins followed by substrate addition and measured for 10 to 40 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetChitinase B(Serratia marcescens)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587857(CHEMBL5199149)
Affinity DataKi:  150nMAssay Description:Inhibition of Serratia marcescens chitinase B expressed in Escherichia coli BL21(DE3) cells using MU-(GlcNAc)2 as a substrate assessed as inhibition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetChitinase B(Serratia marcescens)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587858(CHEMBL1223325 | 9-O-(Benzoyl)Berberrubine Chloride)
Affinity DataKi:  150nMAssay Description:Inhibition of Serratia marcescens chitinase B expressed in Escherichia coli BL21(DE3) cells using MU-(GlcNAc)2 as a substrate assessed as inhibition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetChitinase B(Serratia marcescens)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587859(CHEMBL5180998)
Affinity DataKi:  150nMAssay Description:Inhibition of Serratia marcescens chitinase B expressed in Escherichia coli BL21(DE3) cells using MU-(GlcNAc)2 as a substrate assessed as inhibition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetChitotriosidase-1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587857(CHEMBL5199149)
Affinity DataKi:  350nMAssay Description:Binding affinity to human Cht expressed in Pichia pastoris GS115 using MU-(GlcNAc)2 as substrate assessed as inhibition constant incubated for 25 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAcidic mammalian chitinase(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587857(CHEMBL5199149)
Affinity DataKi:  350nMAssay Description:Inhibition of human AMcase expressed in Pichia pastoris GS115 using MU-(GlcNAc)2 as substrate assesed as inhibition constant incubated for 25 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed