Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50015623
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587869(CHEMBL5174006)
Affinity DataIC50: 1nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587868(CHEMBL5201681)
Affinity DataIC50: 1nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant MNK2 (unknown origin) in presence of ATP by ADP--Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant MNK1 (unknown origin) in presence of ATP by ADP--Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 16nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 23nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587870(CHEMBL5173114)
Affinity DataKi:  40nMAssay Description:Binding affinity to MNK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587866(CHEMBL5182166)
Affinity DataIC50: 40nMAssay Description:Inhibition of GST-tagged MNK1 (unknown origin) expressed in Escherichia coli BL21(DE3) using 5-FAM-TATKSGSTTKNRFVV-NH 2 peptide as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587870(CHEMBL5173114)
Affinity DataKi:  40nMAssay Description:Binding affinity to MNK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587866(CHEMBL5182166)
Affinity DataIC50: 40nMAssay Description:Inhibition of GST-tagged MNK1 (unknown origin) using Ahx-IKKRKLTRRKSLKG-NH2 peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 60nMAssay Description:Inhibition of GST-tagged MNK2 (unknown origin) expressed in Escherichia coli BL21(DE3) using 5-FAM-TATKSGSTTKNRFVV-NH 2 peptide as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587870(CHEMBL5173114)
Affinity DataKi:  150nMAssay Description:Binding affinity to MNK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50079471(CHEMBL3417198)
Affinity DataKi:  300nMAssay Description:Binding affinity to MNK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50079471(CHEMBL3417198)
Affinity DataKi:  300nMAssay Description:Binding affinity to MNK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50130706(CHEMBL3632746)
Affinity DataKi:  320nMAssay Description:Binding affinity to MNK2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 325nMAssay Description:Inhibition of GST-tagged MNK1 (unknown origin) expressed in Escherichia coli BL21(DE3) using 5-FAM-TATKSGSTTKNRFVV-NH 2 peptide as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 870nMAssay Description:Inhibition of MNK1 (unknown origin) using eIF4E as a substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587866(CHEMBL5182166)
Affinity DataIC50: 904nMAssay Description:Inhibition of GST-tagged MNK2 (unknown origin) using Ahx-IKKRKLTRRKSLKG-NH2 peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587867(CHEMBL5199694)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of GST-tagged MNK2 (unknown origin) expressed in Escherichia coli BL21(DE3) using 5-FAM-TATKSGSTTKNRFVV-NH 2 peptide as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MNK2 (unknown origin) using eIF4E as a substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of MNK1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of eIF4E phosphorylation in HEK293 cells incubated for 60 mins by Western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50587867(CHEMBL5199694)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of GST-tagged MNK1 (unknown origin) expressed in Escherichia coli BL21(DE3) using 5-FAM-TATKSGSTTKNRFVV-NH 2 peptide as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed