Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50015629
TargetEpidermal growth factor receptor(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataKd:  67nMAssay Description:Binding affinity to DNA-tagged EGFR (unknown origin) expressed in bacterial system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to DNA-tagged Aurora A (unknown origin) expressed in mammalian system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to DNA-tagged Aurora B (unknown origin) expressed in mammalian system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of Aurora A (unknown origin) using kemptide as substrate incubated for 50 mins in the presence of ATP by ADP-Glo reagent based luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50586459(CHEMBL5080510)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal GST tagged Aurora A (unknown origin) expressed in recombinant baculovirus-infected Sf9 cells using tetra(LRRWSLG) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587906(CHEMBL2382219)
Affinity DataIC50: 35nMAssay Description:Inhibition of Aurora A (unknown origin) using recombinant Lats2-N-ter as substrate incubated in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50539202(CHEMBL4646386)
Affinity DataIC50: 293nMAssay Description:Inhibition Aurora B (unknown origin) by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50539202(CHEMBL4646386)
Affinity DataIC50: 309nMAssay Description:Inhibition Aurora A (unknown origin) by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 431nMAssay Description:Inhibition of EGFR (unknown origin) using Poly(Gly,Tyr) as substrate incubated for 45 mins in the presence of ATP by ADP-Glo reagent based luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587905(CHEMBL5176778)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of human Aurora A using LeuArgArgAlaSerLeuGly as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of Aurora A (unknown origin) using kemptide as substrate incubated for 50 mins in the presence of ATP by ADP-Glo reagent based luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataIC50: 3.76E+3nMAssay Description:Inhibition of EGFR (unknown origin) using Poly(Gly,Tyr) as substrate incubated for 45 mins in the presence of ATP by ADP-Glo reagent based luminescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed