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Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50018245
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408488(CHEMBL5269516)
Affinity DataKd:  0.0290nMAssay Description:Binding affinity to PDE10A (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408487(CHEMBL5281567)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408489(CHEMBL5279257)
Affinity DataKd:  0.0970nMAssay Description:Binding affinity to PDE10A (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408486(CHEMBL5268340)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50497974(CHEMBL3319209)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408477(CHEMBL5275820)
Affinity DataKd:  0.260nMAssay Description:Binding affinity to human PDE4 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PDE8B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50398017(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM290889(US9579407, Example 00162 | 1-[2-fluoro-4- (tetrahy...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM566472(US11419874, ND-7001 | 3-(8-methoxy-1- methyl-2-oxo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50444038(CHEMBL3092563 | US9669035, B-5)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PDE2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50042058((4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrroli...)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to human PDE4 assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408479(CHEMBL5180503)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408480(CHEMBL5270086)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50365964(CHEMBL2070530 | CHEMBL1956235)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408481(CHEMBL5288336)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50357701(CHEMBL1915725 | US9138494, Janssen B-3)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50407408(CHEMBL5267226)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PDE2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to full length human PDE10A assessed as dissociation constant using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50407410(CHEMBL5276846)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human PDE2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408480(CHEMBL5270086)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408481(CHEMBL5288336)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataKd:  6.60nMAssay Description:Binding affinity to full length human PDE10A assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408484(CHEMBL5286170)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408485(CHEMBL5272525)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human PDE4D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human PDE4D7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408484(CHEMBL5286170)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PDE2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408482(CHEMBL5270640)
Affinity DataIC50: 13nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50444038(CHEMBL3092563 | US9669035, B-5)
Affinity DataIC50: 14nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM14768((R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrol...)
Affinity DataIC50: 16nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408478(CHEMBL5196667)
Affinity DataIC50: 17nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant PDE11More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408483(CHEMBL5272911)
Affinity DataIC50: 170nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM86639(BC11-15 | US9173884, BC11-15)
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant PDE11More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50277784(N,N,2-trimethyl-5-nitrobenzenesulfonamide | CHEMBL...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human PDE7A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM86642(BC11-38 | US9173884, BC11-38)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant PDE11More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM60808(BDBM86640 | US9173884, BC11-19)
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant PDE11More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM86643(BC11-38-1 | US9173884, BC11-38-1)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant PDE11More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50408485(CHEMBL5272525)
Affinity DataIC50: 913nMAssay Description:Inhibition of human PDE2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50407408(CHEMBL5267226)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM86644(BC11-38-2 | US9173884, BC11-38-2)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human recombinant PDE11More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM86645(BC11-38-3 | US9173884, BC11-38-3)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human recombinant PDE11More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50277784(N,N,2-trimethyl-5-nitrobenzenesulfonamide | CHEMBL...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of human PDE1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
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