Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 50017404
TargetGlycogen synthase kinase-3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50252729(CHEMBL3216659 | CHEMBL522503 | (2''Z-3''E)-6-Bromo...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM559460(US11370779, Compound 28 | BDBM50564368)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Pig)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50: 5nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50546117(CHEMBL4763626)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM559439(US11370779, Compound 7)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant Tyk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant c-Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant Lyn (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase HCK(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant Hck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 22nMAssay Description:Inhibition of GSK3beta (unknown origin) assessed as decrease in tau phosphorylation at Ser214 residue incubated for 30 mins by Western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Pig)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 22nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50593898(CHEMBL1208600)
Affinity DataIC50: 35nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50593898(CHEMBL1208600)
Affinity DataIC50: 65nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50: 83nMAssay Description:Inhibition of GST-fused CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase C(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50601615(CHEMBL3265229)
Affinity DataIC50: 100nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 100nMAssay Description:Inhibition of GST-fused CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase C(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50: 100nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 101nMAssay Description:Inhibition of recombinant FLT3 D835Y mutant (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 101nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 190nMAssay Description:Inhibition of GSK3beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50546117(CHEMBL4763626)
Affinity DataIC50: 222nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50: 239nMAssay Description:Inhibition of c-met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 300nMAssay Description:Inhibition of LCK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50593898(CHEMBL1208600)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50601613(CHEMBL5186063)
Affinity DataIC50: 370nMAssay Description:Inhibition of Aurora A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 380nMAssay Description:Inhibition of SGK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50: 430nMAssay Description:Inhibition of recombinant c-Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 440nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50: 523nMAssay Description:Inhibition of recombinant JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 590nMAssay Description:Inhibition of GST-fused human CDK2/cyclin A expressed in Escherichia coli using histone H1 as substrate in presence of [33p]-gamma ATP and MgATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50564376(CHEMBL4781229 | US11370779, Compound 4)
Affinity DataIC50: 690nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50: 950nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50: 950nMAssay Description:Inhibition of c-SRC in human MDA-MB-468 cells in presence of [gamma-32P]ATP and ATP by immunoprecipitation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Pig)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50601610(CHEMBL5194837)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant GST-fused PDK1 expressed in Sf9 cells incubated for 30 mins in presence of [gamma-33P]ATP by scintillation counter an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM559434(US11370779, Compound 1)
Affinity DataIC50: 3.19E+3nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 3.33E+3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM559439(US11370779, Compound 7)
Affinity DataIC50: 7.89E+3nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50601615(CHEMBL3265229)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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