Compile Data Set for Download or QSAR
Report error Found 59 Enz. Inhib. hit(s) with all data for entry = 50018259
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408842(CHEMBL5277251)
Affinity DataIC50: 256nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408843(CHEMBL5274589)
Affinity DataIC50: 282nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408841(CHEMBL5281352)
Affinity DataIC50: 319nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408841(CHEMBL5281352)
Affinity DataIC50: 319nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408845(CHEMBL5267327)
Affinity DataIC50: 319nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408844(CHEMBL5280037)
Affinity DataIC50: 368nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408846(CHEMBL5270531)
Affinity DataIC50: 495nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human SIRT6 using H3K9 myristoyl-peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human SIRT6 using H3K9 myristoyl-peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  2.02E+3nMAssay Description:Inhibition of SIRT6 deacetylation (unknown origin) using H3K9Ac peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50135169((2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-tagged SIRT6 (unknown origin) deacetylase activity using H3K9Ac peptide substrate by reversed-phase HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50135169((2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-SIRT6 (unknown origin) assessed as deacetylation reaction using calf thymus histone as substrate by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM29080(Oleamide MEA | Oleoyl monoethanolamide | CHEMBL280...)
Affinity DataEC50:  3.10E+3nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM29080(Oleamide MEA | Oleoyl monoethanolamide | CHEMBL280...)
Affinity DataEC50:  3.10E+3nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  4.62E+3nMAssay Description:Inhibition of SIRT6 deacetylation (unknown origin) using p53K382Ac peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50236531((2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of GST-tagged SIRT6 (unknown origin) deacetylase activity using H3K9Ac peptide substrate by reversed-phase HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408839(CHEMBL5275868)
Affinity DataEC50:  5.70E+3nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408847(CHEMBL5281841)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of GST-SIRT6 (unknown origin) assessed as deacetylation reaction demyristoylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50248235(CHEMBL350239 | CHEBI:5136)
Affinity DataEC50:  7.10E+3nMAssay Description:Activation of human SIRT6 in human HepG2 cells assessed as decrease in H3K56 acetylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50248235(CHEMBL350239 | CHEBI:5136)
Affinity DataEC50:  7.10E+3nMAssay Description:Activation of human SIRT6 in human HepG2 cells assessed as decrease in H3K9 acetylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408838(CHEMBL5277451)
Affinity DataEC50:  7.50E+3nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408836(CHEMBL5270371)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human SIRT6 using H3K9 myristoyl-peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataEC50:  1.03E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activity using EALPKK-Myr-AMC substrate incubated for 2 hrs by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408840(CHEMBL5271662)
Affinity DataKi:  1.34E+4nMAssay Description:Competitive inhibition of SIRT6 (unknown origin) demyristoylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408840(CHEMBL5271662)
Affinity DataEC50:  1.55E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50451275(CHEMBL4205716)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM228816(5-Cl-PZA)
Affinity DataIC50: 3.32E+4nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM228816(5-Cl-PZA)
Affinity DataIC50: 3.32E+4nMAssay Description:Inhibition of human SIRT6 using labeled peptide Acp53 (Ac-Arg-His-Lys-Lys (Ac)-AMC) substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50451274(CHEMBL4206619)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50540048(CHEMBL4636092)
Affinity DataEC50:  3.80E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM228815(5-MeO-PZA)
Affinity DataIC50: 4.04E+4nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human SIRT6 demyristoylation reaction assessed as deacylation using H3K9 decanoyl peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408837(CHEMBL5273512)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408837(CHEMBL5273512)
Affinity DataEC50:  7.00E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activity assessed as demyristoylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50460478(CHEMBL4226903)
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of full length GST-tagged SIRT6 (unknown origin) assessed as de-octanoylation using acyl substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataEC50:  8.90E+4nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50460478(CHEMBL4226903)
Affinity DataIC50: 8.90E+4nMAssay Description:Inhibition of full length GST-tagged SIRT6 (unknown origin) assessed as demyristoylation using acyl substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataEC50:  9.00E+4nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408837(CHEMBL5273512)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of SIRT6 deacetylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM22231(CHEMBL267476 | (9Z,12Z)-octadeca-9,12-dienoic acid...)
Affinity DataEC50:  1.00E+5nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408837(CHEMBL5273512)
Affinity DataIC50: 1.02E+5nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of SIRT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of full length GST-tagged SIRT6 (unknown origin) assessed as demyristoylation using acyl substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of full length GST-tagged SIRT6 (unknown origin) assessed as de-octanoylation using acyl substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.53E+5nMAssay Description:Inhibition of SIRT6 (unknown origin) deacylation using fluorogenic substrate AcEALPK(MyrK)-AMC by HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408837(CHEMBL5273512)
Affinity DataIC50: 1.57E+5nMAssay Description:Inhibition of SIRT1 deacetylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50408837(CHEMBL5273512)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of SIRT2 deacetylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.84E+5nMAssay Description:Inhibition of SIRT6 (unknown origin) deacylation using fluorogenic substrate AcEALPK(MyrK)-AMC by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.84E+5nMAssay Description:Inhibition of human SIRT6 demyristoylation reaction assessed as deacylation using H3K9 hexanoyl-peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Displayed 1 to 50 (of 59 total ) | Next | Last >>
Jump to: