Compile Data Set for Download or QSAR
Report error Found 176 Enz. Inhib. hit(s) with all data for entry = 50017407
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388435(US10294246, Compound No. 132)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388321(US10294246, Compound No. 18)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601652(CHEMBL5191857)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388309(US10294246, Compound No. 6)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388395(US10294246, Compound No. 92)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388323(US10294246, Compound No. 20)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388311(US10294246, Compound No. 8)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388437(US10294246, Compound No. 134)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388428(US10294246, Compound No. 125)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388427(US10294246, Compound No. 124)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388408(US10294246, Compound No. 105)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601643(CHEMBL5184466)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601643(CHEMBL5184466)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601649(CHEMBL5173345)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388388(US10294246, Compound No. 85)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388433(US10294246, Compound No. 130)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388378(US10294246, Compound No. 75)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388393(US10294246, Compound No. 90)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601653(CHEMBL5200546)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601651(CHEMBL5175203)
Affinity DataIC50: 6nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388429(US10294246, Compound No. 126)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388395(US10294246, Compound No. 92)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601656(CHEMBL5201811)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388322(US10294246, Compound No. 19)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601652(CHEMBL5191857)
Affinity DataIC50: 11nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-10(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 13nMAssay Description:Inhibition of human 20S immunoproteasome beta-2i subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388309(US10294246, Compound No. 6)
Affinity DataIC50: 14nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601656(CHEMBL5201811)
Affinity DataIC50: 14nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601657(CHEMBL5177052)
Affinity DataIC50: 15nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388323(US10294246, Compound No. 20)
Affinity DataIC50: 16nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601650(CHEMBL5179619)
Affinity DataIC50: 18nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388321(US10294246, Compound No. 18)
Affinity DataIC50: 18nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388408(US10294246, Compound No. 105)
Affinity DataIC50: 20nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601657(CHEMBL5177052)
Affinity DataIC50: 20nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388428(US10294246, Compound No. 125)
Affinity DataIC50: 23nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human 20S immunoproteasome beta1 subunit using Ac-nLPnLD-AMC as substrate preincubated for 2 hrs followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388435(US10294246, Compound No. 132)
Affinity DataIC50: 25nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM388311(US10294246, Compound No. 8)
Affinity DataIC50: 25nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601650(CHEMBL5179619)
Affinity DataIC50: 27nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601651(CHEMBL5175203)
Affinity DataIC50: 27nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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