Compile Data Set for Download or QSAR
Report error Found 113 Enz. Inhib. hit(s) with all data for entry = 50013501
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566740(CHEMBL4776509)
Affinity DataEC50:  9nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263453((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263445((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263482((s)-2-(8-fluoro-6-methyl-4-oxobenzo[d][1,2,3]triaz...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263440((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263498((s)-n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(4-ox...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263497((s)-n-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263471((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263501((s)-n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(5-me...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263505(n-(4-chlorophenethyl)-2-(4-oxobenzo[d][1,2,3]triaz...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263368((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263490((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263391((s)-n-(1-(4-chlorophenyl)ethyl)-2-(4-oxobenzo[d][1...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263369((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263485((s)-n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(4-oxob...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263433((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566745(CHEMBL4869182)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263420((s)-n-(1-(2,4-dimethylphenyl)ethyl)-2-(4-oxobenzo[...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263502((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263507(n-(4-methylphenethyl)-2-(4-oxobenzo[d][1,2,3]triaz...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263465((s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566743(CHEMBL4847108)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263370((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263454((s)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3 (4h)...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263385((s)-n-(1-(4-methoxyphenyl)ethyl)-2-(4-oxobenzo[d][...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566752(CHEMBL4874147)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263504((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataKi:  33nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263483((s)-n-(1-(2-methoxy-4-methylphenyl)ethyl)-2-(4-oxo...)
Affinity DataEC50:  36nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263480((s)-2-(4-oxo-6-(trifluoromethyl)benzo[d][1,2,3]tri...)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566729(CHEMBL1380104)
Affinity DataEC50:  46nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263369((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  48nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566738(CHEMBL4861019)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263510((s)-n-(1-(4-methoxyphenyl)propan-2-yl)-2-(4-oxoben...)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263504((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataEC50:  58nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263453((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  58nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263420((s)-n-(1-(2,4-dimethylphenyl)ethyl)-2-(4-oxobenzo[...)
Affinity DataKi:  63nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263506(n-(3-chlorophenethyl)-2-(4-oxobenzo[d][1,2,3]triaz...)
Affinity DataEC50:  65nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566747(CHEMBL1460960)
Affinity DataEC50:  66nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263435((s)-n-(1-(4-ethoxyphenyl)ethyl)-2-(4-oxobenzo[d][1...)
Affinity DataEC50:  67nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566728(CHEMBL4866435)
Affinity DataEC50:  68nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263490((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  76nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566756(CHEMBL4855076)
Affinity DataEC50:  77nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566735(CHEMBL4860510)
Affinity DataEC50:  79nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263482((s)-2-(8-fluoro-6-methyl-4-oxobenzo[d][1,2,3]triaz...)
Affinity DataKi:  85nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566730(CHEMBL4869485)
Affinity DataEC50:  85nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566744(CHEMBL4871506)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263437((s)-n-(1-(2,4-dimethoxyphenyl)ethyl)-2-(4-oxobenzo...)
Affinity DataEC50:  91nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566736(CHEMBL4874254)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263368((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataKi:  119nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566754(CHEMBL4871591)
Affinity DataEC50:  119nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
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