Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50014136
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572945(CHEMBL4850429)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572943(CHEMBL4872157)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572941(CHEMBL4871067)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572936(CHEMBL4858196)
Affinity DataIC50: 28nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572940(CHEMBL4868783)
Affinity DataIC50: 38nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Rat)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 47nMAssay Description:Inhibition of LPA in rat plasma after 18 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 53nMAssay Description:Inhibition of LPA in human plasma after 18 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572942(CHEMBL4859055)
Affinity DataIC50: 100nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572948(CHEMBL1615121 | CHEBI:62833)
Affinity DataIC50: 110nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572946(CHEMBL4847281)
Affinity DataIC50: 230nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572944(CHEMBL4858465)
Affinity DataIC50: 330nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572939(CHEMBL4846048)
Affinity DataIC50: 370nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572938(CHEMBL4872976)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572937(CHEMBL4875797)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 3(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPA3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 2(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPA2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 5(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPA5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of S1P5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of S1P4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of S1P3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of S1P2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of S1P1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes incubated for 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50572947(CHEMBL4871014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes incubated for 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed