Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50017977
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50318633(SB-742457 | 3-benzenesulfonyl-8-piperazin-1-ylquin...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044615(CHEMBL3329435)
Affinity DataKi:  0.530nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM34152(CHEMBL362628 | E-6801)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50415977(CHEMBL1085113)
Affinity DataKi:  0.630nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50019754(LU-AE58054 | IDALOPIRDINE)
Affinity DataKi:  0.830nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606660(CHEMBL5220473)
Affinity DataKi:  0.980nMAssay Description:Displacement of [125I]cAMP-tracer from 5-HT6R in human HeLa cells assessed as measuring cAMP level incubated for 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606653(CHEMBL5219333)
Affinity DataKi: <1nMAssay Description:Binding affinity to 5-HT1A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606652(CHEMBL5218527)
Affinity DataKi:  1nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044616(Cerlapirdine | PF-05212365 | SAM-531 | WAY-262531)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human SERT assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606655(CHEMBL5219924)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to D2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606656(CHEMBL4117763)
Affinity DataKi:  2nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606655(CHEMBL5219924)
Affinity DataKi:  2nMAssay Description:Binding affinity to 5-HT2AR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM81790(NSC_2159 | CAS_71675-85-9 | Amisulpride | US101672...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N-methyl-spiperone from D2R (unknown origin) assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50458523(JNJ-18038683)
Affinity DataKi:  3nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM81790(NSC_2159 | CAS_71675-85-9 | Amisulpride | US101672...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]N-methyl-spiperone from D3R (unknown origin) assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity to human 5-HT3R assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044601(CHEMBL3329445)
Affinity DataKi:  4nMAssay Description:Displacement of LSD from recombinant human 5-HT6R assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H] LSD from 5-HT6R in human HeLa cells assessed as inhibition constant incubated for 120 mins in presence of methiothepin by scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606657(CHEMBL5219467)
Affinity DataKi:  7nMAssay Description:Displacement of [3H] LSD from recombinant human 5-HT6R expressed in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  8nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606658(CHEMBL5220504)
Affinity DataKi:  9nMAssay Description:Displacement of [3H] LSD from human 5-HT6R expressed in HEK293 cell membrane assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM11638(N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sul...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to D2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50516529(CHEMBL4520796)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]LSD from 5-HT6R (unknown origin) expressed in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606655(CHEMBL5219924)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha2C AR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM81790(NSC_2159 | CAS_71675-85-9 | Amisulpride | US101672...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataKi:  15nMAssay Description:Binding affinity to human 5-HT1A assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50400902(CHEMBL2204360 | vortioxetine hydrobromide | 1-(2-(...)
Affinity DataKi:  19nMAssay Description:Binding affinity to human 5-HT7R assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606659(CHEMBL5220242)
Affinity DataKi:  30nMAssay Description:Displacement of [3H] LSD from 5-HT6R in HEK293 cells assessed as inhibition constant incubated for 1 hr in presence of haloperidol by microbeta plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataKi:  34nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606653(CHEMBL5219333)
Affinity DataKi:  34nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606654(CHEMBL5219968)
Affinity DataKi:  41nMAssay Description:Binding affinity to 5-HT1A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50068233(CHEMBL1580288)
Affinity DataKi:  119nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606654(CHEMBL5219968)
Affinity DataKi:  156nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM11638(N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sul...)
Affinity DataKi: >3.00E+3nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606653(CHEMBL5219333)
Affinity DataKi:  9.62E+3nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606654(CHEMBL5219968)
Affinity DataKi:  9.97E+3nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed