Compile Data Set for Download or QSAR
Report error Found 127 Enz. Inhib. hit(s) with all data for entry = 50017415
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to RET (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataKd:  36nMAssay Description:Binding affinity to BRAF (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataKd:  14nMAssay Description:Binding affinity to BRAF V600E (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataKd:  39nMAssay Description:Binding affinity to CRAF (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to ABL (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataKd:  7.90nMAssay Description:Binding affinity to VEGFR2 (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataKd:  14nMAssay Description:Binding affinity to FLT-1 (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to C-KIT (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of human recombinant full length VEGFR2 in presence of ATP by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of FLT3 (unknown origin) by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant RET V804L (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wildtype RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wildtype RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of NCOA4-RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of recombinant RET V804L (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BCR-ABL (unknown origin) by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSAFB-like transcription modulator(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant full length c-Met in presence of ATP by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of RET (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601764(CHEMBL5201128)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of RET (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ALK L1196M (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of ALK (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601765(CHEMBL5201102)
Affinity DataIC50: 2nMAssay Description:Inhibition of RET (unknown origin) by FISH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1/2/3/4(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of FGFR (unknown origin) by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of RAF1 (305 to 648 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601765(CHEMBL5201102)
Affinity DataIC50: 3nMAssay Description:Inhibition of VEGFR2 (unknown origin) by FISH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601764(CHEMBL5201128)
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR2 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601765(CHEMBL5201102)
Affinity DataIC50: 4nMAssay Description:Inhibition of VEGFR3 (unknown origin) by FISH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of VEGFR2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of RET M918T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetStromelysin-3(Mouse)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.5nMAssay Description:Antiproliferative activity against human NB1 cells harbouring ALK by CellTiter-Glo luminescent cell viability assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human recombinant full length c-Kit in presence of ATP by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant RET using Biotin-EGPWLEEEEEAYGWMDFas substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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