Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50014057
TargetProgesterone receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of progesterone receptor (unknown origin) by fluorescence polarization based competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572209(CHEMBL4858977)
Affinity DataEC50:  609nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572210(CHEMBL4846941)
Affinity DataEC50:  62nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572214(CHEMBL4870156)
Affinity DataEC50:  187nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572218(CHEMBL4872481)
Affinity DataEC50:  415nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572219(CHEMBL4868096)
Affinity DataEC50:  2.62E+3nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572220(CHEMBL4858615)
Affinity DataEC50:  921nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572204(CHEMBL4865454)
Affinity DataEC50:  227nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Agonist activity at human RORalpha (272 to 557 residues) co-expressed with Gal4-luciferase reporter in human Jurkat cells incubated for 18 hrs by Ste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50:  350nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of glucocorticoid receptor (unknown origin) by fluorescence polarization based competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of estrogen receptor alpha (unknown origin) by fluorescence polarization based competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of androgen receptor (unknown origin) by fluorescence polarization based competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of human LXRbeta co-expressed with TK-luciferase reporter in African green monkey CV-1 cells incubated for overnight by Steady-Glo lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of PPARalpha LBD (unknown origin) co-expressed with Gal4UAS-luciferase reporter in HEK293 cells incubated for 24 hrs by Steady-Glo lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of PPARgamma LBD (unknown origin) co-expressed with Gal4UAS-luciferase reporter in HEK293 cells incubated for 24 hrs by Steady-Glo lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of PPARdelta LBD (unknown origin) co-expressed with Gal4UAS-luciferase reporter in HEK293 cells incubated for 24 hrs by Steady-Glo lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of human LXRalpha co-expressed with TK-luciferase reporter in African green monkey CV-1 cells incubated for overnight by Steady-Glo lucife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataEC50:  53nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572205(CHEMBL4863612)
Affinity DataEC50:  1.36E+3nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572206(CHEMBL4858238)
Affinity DataEC50:  21nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572207(CHEMBL4870766)
Affinity DataEC50:  11nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572208(CHEMBL4846545)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572209(CHEMBL4858977)
Affinity DataEC50:  120nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572210(CHEMBL4846941)
Affinity DataEC50:  7.10nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572211(CHEMBL4846002)
Affinity DataEC50:  202nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572212(CHEMBL4874257)
Affinity DataEC50:  14nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572213(CHEMBL4851875)
Affinity DataEC50:  50nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572214(CHEMBL4870156)
Affinity DataEC50:  25nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572207(CHEMBL4870766)
Affinity DataEC50:  23nMAssay Description:Agonist activity at His-tagged human FXR LBD assessed as induction of coactivator SRC-1 peptide recruitment measured after 30 mins by plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572216(CHEMBL4868516)
Affinity DataEC50:  342nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572217(CHEMBL4853954)
Affinity DataEC50:  45nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572215(CHEMBL4875500)
Affinity DataEC50:  31nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572218(CHEMBL4872481)
Affinity DataEC50:  63nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572219(CHEMBL4868096)
Affinity DataEC50:  522nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572220(CHEMBL4858615)
Affinity DataEC50:  206nMAssay Description:Agonist activity at Gal4-fused human FXR expressed in HEK293 cells incubated for overnight by Steady-Glo luciferase reporter gene based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572210(CHEMBL4846941)
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572213(CHEMBL4851875)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572215(CHEMBL4875500)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572214(CHEMBL4870156)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572218(CHEMBL4872481)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572219(CHEMBL4868096)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572221(CHEMBL4862974)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572220(CHEMBL4858615)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572218(CHEMBL4872481)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572216(CHEMBL4868516)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572213(CHEMBL4851875)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572210(CHEMBL4846941)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572216(CHEMBL4868516)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50572214(CHEMBL4870156)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin) expressed in baculovirus infected insect supersomes preincubated for 15 mins followed by addition of NADPH rege...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
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