Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50018667
TargetProstaglandin E2 receptor EP3 subtype(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50610935(SEPETAPROST | Sepetaprost | Ono-9054 | DE-126 | ON...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at EP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50610936(ONO-AG-367 | Ono-ag-367)
Affinity DataEC50:  29nMAssay Description:Agonist activity at EP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50610935(SEPETAPROST | Sepetaprost | Ono-9054 | DE-126 | ON...)
Affinity DataEC50:  3.03E+3nMAssay Description:Agonist activity at FP receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50610936(ONO-AG-367 | Ono-ag-367)
Affinity DataEC50:  22nMAssay Description:Agonist activity at FP receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50610937(CHEMBL5272661)
Affinity DataIC50: 2nMAssay Description:Agonist activity at human EP4 receptor expressed in CHO cells co-transfected with CRE-beta-lactamase reporter gene assessed as increase in intracellu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50: 2nMAssay Description:Agonist activity at human EP4 receptor expressed in CHO cells co-transfected with CRE-beta-lactamase reporter gene assessed as increase in intracellu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 19nMAssay Description:Inhibition of Rock2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50: 51nMAssay Description:Inhibition of Rock1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAutotaxin(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50610938(CHEMBL5269381)
Affinity DataIC50: 110nMAssay Description:Inhibition of ATX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50546247(Netarsudil | AR-11324 FREE BASE | AR-13324 | US114...)
Affinity DataKi:  1nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50546247(Netarsudil | AR-11324 FREE BASE | AR-13324 | US114...)
Affinity DataKi:  1nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor transfected with HEK293 cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50610937(CHEMBL5272661)
Affinity DataKi: <2nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor transfected with HEK293 cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50546247(Netarsudil | AR-11324 FREE BASE | AR-13324 | US114...)
Affinity DataKi:  2nMAssay Description:Inhibition of Rock2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Chengdu Sport University

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to EP2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed