Compile Data Set for Download or QSAR
Report error Found 67 Enz. Inhib. hit(s) with all data for entry = 50015453
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116254(US8637508, 31 | US10035794, Example 31 | US1068328...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta(1 to 40 residues) levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta42 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116236(US8637508, 11 | US10035794, Example 11 | US1068328...)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116247(US8637508, 24 | US10035794, Example 24 | US1068328...)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta40 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50012653(CHEMBL3261067)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50012653(CHEMBL3261067)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116236(US8637508, 11 | US10035794, Example 11 | US1068328...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116250(US8637508, 27 | US10035794, Example 27 | US1068328...)
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116247(US8637508, 24 | US10035794, Example 24 | US1068328...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116250(US8637508, 27 | US10035794, Example 27 | US1068328...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116254(US8637508, 31 | US10035794, Example 31 | US1068328...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116236(US8637508, 11 | US10035794, Example 11 | US1068328...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116254(US8637508, 31 | US10035794, Example 31 | US1068328...)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116247(US8637508, 24 | US10035794, Example 24 | US1068328...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116250(US8637508, 27 | US10035794, Example 27 | US1068328...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586754(CHEMBL5080033)
Affinity DataIC50: 23nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116253(US8637508, 30 | US10035794, Example 30 | US1068328...)
Affinity DataIC50: 24nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116253(US8637508, 30 | US10035794, Example 30 | US1068328...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116253(US8637508, 30 | US10035794, Example 30 | US1068328...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116267(US8637508, 44 | US10035794, Example 44 | US1068328...)
Affinity DataIC50: 26nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586755(CHEMBL5070669)
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116267(US8637508, 44 | US10035794, Example 44 | US1068328...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586755(CHEMBL5070669)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586754(CHEMBL5080033)
Affinity DataIC50: 71nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50012653(CHEMBL3261067)
Affinity DataIC50: 98nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116240(US8637508, 16 | US10035794, Example 16 | US1068328...)
Affinity DataIC50: 98nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116267(US8637508, 44 | US10035794, Example 44 | US1068328...)
Affinity DataIC50: 143nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586755(CHEMBL5070669)
Affinity DataIC50: 182nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586753(CHEMBL5089745)
Affinity DataIC50: 263nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116249(US8637508, 26 | US10035794, Example 26)
Affinity DataIC50: 284nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116249(US8637508, 26 | US10035794, Example 26)
Affinity DataIC50: 402nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586753(CHEMBL5089745)
Affinity DataIC50: 696nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586754(CHEMBL5080033)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50586753(CHEMBL5089745)
Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 3.20E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116249(US8637508, 26 | US10035794, Example 26)
Affinity DataIC50: 6.41E+3nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 1.09E+4nMAssay Description:Irreversible inhibition of CYP3A4 in human liver microsomes incubated for 10 mins in presence of NADPH by mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 1.34E+4nMAssay Description:Irreversible inhibition of CYP2D6 in human liver microsomes incubated for 10 mins in presence of NADPH by mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCathepsin D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116250(US8637508, 27 | US10035794, Example 27 | US1068328...)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of human Cathepsin D using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 2.00E+4nMAssay Description:Irreversible inhibition of CYP2C9 in human liver microsomes incubated for 10 mins in presence of NADPH by mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
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