Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50014764
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to recombinant human His6-tagged HDM2 (1 to 118 residues) assessed as reduction in PMDM6-F binding incubated for 15 to 30 mins by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50579900(CHEMBL5079085)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to HDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50437206(CHEMBL2402737 | US20250073340, Example RG7388)
Affinity DataKd:  9.80nMAssay Description:Binding affinity to HDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant human GST-tagged HDM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 800nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM135112(US8846657, 3.2)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed