Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50016851
TargetAmine oxidase [flavin-containing] B(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM166636(7-[(4-Chlorobenzyl)oxy]-3,4-dihydronaphthalen-1(2H...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human MAO-B assessed as measuring amount of 4-hydroxyquinoline using kynuramine as substrate incubated for 20 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM166630(7-(Benzyloxy)-3,4-dihydronaphthalen-1(2H)-one (4a))
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human MAO-B using kynuramine as substrate by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM166640(7-[(4-Methylbenzyl)oxy]-3,4-dihydronaphthalen-1(2H...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human MAO-B using kynuramine as substrate by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of BuChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] B(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597771(CHEMBL5178423)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM166630(7-(Benzyloxy)-3,4-dihydronaphthalen-1(2H)-one (4a))
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human MAO-A using kynuramine as substrate by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597770(CHEMBL5182438)
Affinity DataIC50: 13nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 32nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM166636(7-[(4-Chlorobenzyl)oxy]-3,4-dihydronaphthalen-1(2H...)
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human MAO-A assessed as measuring amount of 4-hydroxyquinoline using kynuramine as substrate incubated for 20 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597778(CHEMBL5181051)
Affinity DataIC50: 45nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Bovine)
Northwest University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant bovine mitochondrial MAO-A using benzylamine or serotonin as substrate incubated for 60 mins by fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM166642(7-[(4-Cyanobenzyl)oxy]-3,4-dihydronaphthalen-1(2H)...)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant human MAO-B using kynuramine as substrate by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 59nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM166642(7-[(4-Cyanobenzyl)oxy]-3,4-dihydronaphthalen-1(2H)...)
Affinity DataIC50: 366nMAssay Description:Inhibition of recombinant human MAO-A using kynuramine as substrate by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597780(CHEMBL5202485)
Affinity DataIC50: 570nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597769(CHEMBL5190154)
Affinity DataIC50: 707nMAssay Description:Inhibition of human MAO-B assessed as measuring amount of 4-hydroxyquinoline using kynuramine as substrate incubated for 20 mins by fluorescence spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM166640(7-[(4-Methylbenzyl)oxy]-3,4-dihydronaphthalen-1(2H...)
Affinity DataIC50: 741nMAssay Description:Inhibition of recombinant human MAO-A using kynuramine as substrate by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597770(CHEMBL5182438)
Affinity DataIC50: 754nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50155481(2-{1-[2,5-di(trifluoromethyl)phenyl]methylidene}-6...)
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP24 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Bovine)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597778(CHEMBL5181051)
Affinity DataIC50: 920nMAssay Description:Inhibition of recombinant bovine mitochondrial MAO-A using benzylamine or serotonin as substrate incubated for 60 mins by fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Bovine)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597780(CHEMBL5202485)
Affinity DataIC50: 990nMAssay Description:Inhibition of recombinant bovine mitochondrial MAO-A using benzylamine or serotonin as substrate incubated for 60 mins by fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Bovine)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597779(CHEMBL5205498)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of recombinant bovine mitochondrial MAO-A using benzylamine or serotonin as substrate incubated for 60 mins by fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597768(CHEMBL5184006)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of human MAO-A assessed as measuring amount of 4-hydroxyquinoline using kynuramine as substrate incubated for 20 mins by fluorescence spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597771(CHEMBL5178423)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597769(CHEMBL5190154)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of human MAO-A assessed as measuring amount of 4-hydroxyquinoline using kynuramine as substrate incubated for 20 mins by fluorescence spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597779(CHEMBL5205498)
Affinity DataIC50: 2.92E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50155469(2-(4-hydroxybenzyl)-6-methoxy-3,4-dihydro-2H-napht...)
Affinity DataIC50: 3.50E+3nMAssay Description:Displacement of 25-hydroxy-[26,27-methyl-3H]-vitamin D3 from CYP24 in 1,25(OH)2D3-treated human DU-145 cells using 25-(OH)D3 as substrate pretreated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597776(CHEMBL5183631)
Affinity DataIC50: 4.34E+3nMAssay Description:Displacement of [3H]DPCPX from A1AR in rat whole brain membrane assessed as inhibition constant by radioligand competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597780(CHEMBL5202485)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of BuChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of BuChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597777(CHEMBL5187030)
Affinity DataIC50: 6.84E+3nMAssay Description:Displacement of [3H]DPCPX from A1AR in rat whole brain membrane assessed as inhibition constant by radioligand competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597777(CHEMBL5187030)
Affinity DataIC50: 7.05E+3nMAssay Description:Displacement of [3H]NECA from A2AAR in rat striatal membrane assessed as inhibition constant by radioligand competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597778(CHEMBL5181051)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of BuChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597779(CHEMBL5205498)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of BuChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Bovine)
Northwest University

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 8.28E+5nMAssay Description:Inhibition of recombinant bovine mitochondrial MAO-A using benzylamine or serotonin as substrate incubated for 60 mins by fluorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597763(CHEMBL5203969)
Affinity DataIC50: 9.49E+5nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597760(4,8-DIHYDROXY-1-TETRALONE)
Affinity DataIC50: 5.69E+8nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597762(CHEMBL5190764)
Affinity DataIC50: 1.08E+6nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597761(CHEMBL5202625)
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50409510(CHEMBL308480)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to 5-HT2A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50223744(CHEMBL155486)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to 5-HT2A receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597775(CHEMBL5198566)
Affinity DataKi:  1.61E+3nMAssay Description:Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597773(CHEMBL4535634)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of [3H]DPCPX from A1AR in rat whole brain assessed as inhibition constant by radioligand competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597774(CHEMBL5178192)
Affinity DataKi:  1.64E+3nMAssay Description:Displacement of [3H]DPCPX from A1AR in rat whole brain assessed as inhibition constant by radioligand competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597767(CHEMBL5200123)
Affinity DataKi:  4.70E+3nMAssay Description:Displacement of isotopically-labeled PPAR-gamma (unknown origin) assessed as inhibition constant by competitive inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597766(CHEMBL5198152)
Affinity DataKi:  4.90E+3nMAssay Description:Displacement of isotopically-labeled PPAR-gamma (unknown origin) assessed as inhibition constant by competitive inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597773(CHEMBL4535634)
Affinity DataKi:  5.46E+3nMAssay Description:Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597764(CHEMBL5197814)
Affinity DataKi:  5.80E+3nMAssay Description:Displacement of isotopically-labeled PPAR-gamma (unknown origin) assessed as inhibition constant by competitive inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597774(CHEMBL5178192)
Affinity DataKi:  9.92E+3nMAssay Description:Displacement of [3H]NECA from A2AAR in rat striata assessed as inhibition constant in presence of N6-cyclopentyladenosine by radioligand competitive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50597775(CHEMBL5198566)
Affinity DataKi:  1.14E+4nMAssay Description:Displacement of [3H]DPCPX from A1AR in rat whole brain assessed as inhibition constant by radioligand competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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