Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50016403
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594741(CHEMBL5205088)
Affinity DataIC50: 1nMAssay Description:Inverse agonist activity at recombinant 6His-tagged human RORgamma LBD (264 to 518 residues) assessed as inhibition of biotinylated RIP140 co-activat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594742(CHEMBL5205002)
Affinity DataIC50: 2.30nMAssay Description:Inverse agonist activity at recombinant 6His-tagged human RORgamma LBD (264 to 518 residues) assessed as inhibition of biotinylated RIP140 co-activat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594738(CHEMBL5202889)
Affinity DataIC50: 3.60nMAssay Description:Inverse agonist activity at RORgammat expressed in Jurkat cells co-transfected with luciferase reporter vector expressing human IL-17 ROR response el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM310631(US10150762, Example 2/16)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of GAL4 DNA-binding domain fused full length human RORgammat (1 to 497 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50106286(CHEMBL3598141 | US9550771, Example 27)
Affinity DataEC50:  10nMAssay Description:Inverse agonist activity at RORC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataEC50:  16nMAssay Description:Inverse agonist activity at RORC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594739(CHEMBL5180156)
Affinity DataIC50: 30nMAssay Description:Inhibition of ROR gamma (unknown origin) by FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594741(CHEMBL5205088)
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at recombinant Gal4-fused human RORgammat LBD expressed in Jurkat cells assessed as luciferase activity measured after 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594740(CHEMBL5205826)
Affinity DataIC50: 40nMAssay Description:Inverse agonist activity at ROR gamma (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594740(CHEMBL5205826)
Affinity DataIC50: 40nMAssay Description:Inverse agonist activity at ROR gamma (unknown origin) by FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50534854(CHEMBL4544537)
Affinity DataIC50: 60nMAssay Description:Agonist activity at ROR gamma (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594739(CHEMBL5180156)
Affinity DataIC50: 100nMAssay Description:Inhibition of ROR gamma (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50106301(CHEMBL3598140)
Affinity DataIC50: 130nMAssay Description:Inverse agonist activity at human PPARgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50012122(CHEMBL3263695)
Affinity DataIC50: 370nMAssay Description:Inhibition of RORC LBD (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594737(CHEMBL5208942)
Affinity DataIC50: 820nMAssay Description:Inverse agonist activity at full length RORC expressed in HEK293T cells co-transfected with Pcp2/RORE-Luc reporter incubated for 24 hrs by dual-lucif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50106286(CHEMBL3598141 | US9550771, Example 27)
Affinity DataIC50: 1.50E+3nMAssay Description:Inverse agonist activity at human PPARgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-beta(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM310631(US10150762, Example 2/16)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GAL4 DNA-binding domain fused full length human RORbeta (201 to 459 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-alpha(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM310631(US10150762, Example 2/16)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GAL4 DNA-binding domain fused full length human RORalpha (305 to 556 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594737(CHEMBL5208942)
Affinity DataIC50: 2.39E+3nMAssay Description:Inverse agonist activity at 6His-tagged human RORC LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50594737(CHEMBL5208942)
Affinity DataIC50: 6.38E+3nMAssay Description:Inverse agonist activity at 6His-tagged human RORC LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50434244(CHEMBL2385908)
Affinity DataIC50: 2.09E+4nMAssay Description:Agonist activity at 6His-tagged human RORC LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of N-termi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed