Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50017533
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602550(CHEMBL5177406)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602553(CHEMBL5204309)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602551(CHEMBL5181317)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50602552(CHEMBL5191501)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Picardy Jules Verne

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed