Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50017588
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  232nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434771(US10562910, Example 2)
Affinity DataEC50:  114nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434773(US10562910, Example 13)
Affinity DataEC50:  5.40nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434774(US10562910, Example 14)
Affinity DataEC50:  7.10nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434776(US10562910, Example 5)
Affinity DataEC50:  102nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603130(CHEMBL5202185)
Affinity DataEC50:  87nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603131(CHEMBL5183931)
Affinity DataEC50:  167nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434770(US10562910, Example 1)
Affinity DataEC50:  219nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434777(US10562910, Example 4)
Affinity DataEC50:  372nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM322138(US10183917, Example 3)
Affinity DataEC50:  3.60nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity in human GPBAR1 assessed as increase in intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetEstrogen receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at estrogen receptor alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at estrogen receptor beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM322140(US10183917, Example 4)
Affinity DataEC50:  161nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM322134(US10183917, Example 1 | 8-((5-cyclopropyl-3-(2,6-d...)
Affinity DataEC50:  833nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603128(CHEMBL5187438)
Affinity DataEC50:  37nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM322140(US10183917, Example 4)
Affinity DataEC50:  12nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603129(CHEMBL5179385)
Affinity DataEC50:  52nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434771(US10562910, Example 2)
Affinity DataEC50:  14nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434773(US10562910, Example 13)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434774(US10562910, Example 14)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434776(US10562910, Example 5)
Affinity DataEC50:  4.80nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603130(CHEMBL5202185)
Affinity DataEC50:  6nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603131(CHEMBL5183931)
Affinity DataEC50:  21nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434770(US10562910, Example 1)
Affinity DataEC50:  17nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM322134(US10183917, Example 1 | 8-((5-cyclopropyl-3-(2,6-d...)
Affinity DataEC50:  345nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM322138(US10183917, Example 3)
Affinity DataEC50:  102nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603129(CHEMBL5179385)
Affinity DataEC50:  477nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataIC50: 5.24E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed