Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50016438
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594985(CHEMBL5182587)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant His-tagged human DHODH expressed in Escherichia coli using dihydroorotate as substrate DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594977(CHEMBL3896992)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DHODH (M30 to R360 residues) by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594980(CHEMBL5206824)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate as substrate and UQ0 as co-substrate by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594978(CHEMBL5193049)
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate as substrate and UQ0 as co-substrate by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594981(CHEMBL5177430)
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate as substrate and UQ0 as co-substrate by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594979(CHEMBL5181885)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate as substrate and UQ0 as co-substrate by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594982(CHEMBL5187875)
Affinity DataIC50: 48nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594986(CHEMBL5202345)
Affinity DataIC50: 93nMAssay Description:Inhibition of human DHODH expressed in Escherichia coli Rosetta 2 (DE3) using dihydroorotate as substrate and CoQ6 as co-substrate incubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594987(CHEMBL2028401)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50441633(Isobacachalcone | 4-Hydroxyisocordoin | ISOBAVACHA...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataIC50: 134nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594976(CHEMBL5178031)
Affinity DataIC50: 148nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate substrate incubated for 30 mins by DCIP dye based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594984(CHEMBL5171775)
Affinity DataIC50: 172nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594983(CHEMBL5176340)
Affinity DataIC50: 210nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50398648(CHEMBL2178104)
Affinity DataIC50: 365nMAssay Description:Inhibition of human DHODH (M30 to R360 residues) by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50594975(CHEMBL5177681)
Affinity DataIC50: 438nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate substrate incubated for 30 mins by DCIP dye based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50512054(CHEMBL4458679)
Affinity DataIC50: 814nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate as substrate and UQ0 as co-substrate by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50148573(1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dieno...)
Affinity DataIC50: 880nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant human DHODH expressed in Escherichia coli strain BL21 (DE3) using dihydroorotate as substrate and Co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM477574(US10889564, Example 3 | (R) N-(1-(2-fluorophenyl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate incubated for 60 mins by DCIP dye based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50148573(1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dieno...)
Affinity DataKi:  710nMAssay Description:Binding affinity to N-terminal 6His-tagged recombinant human DHODH expressed in Escherichia coli strain BL21 (DE3) by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)