Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50015724
TargetD(1A) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM435739(US10611751, Example 1 | 2-(2,6-dichlorophenyl)-1-(...)
Affinity DataEC50:  12nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM435904(US10611751, Example 8 | 2-(2,6-dichlorophenyl)-1-(...)
Affinity DataEC50:  6.40nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM435762(US10611751, Example 2 | 2-(2,6-dichlorophenyl)-1- ...)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM435774(US10611751, Example 3 | 1-((1S,3R)-5-(1-cyclopropy...)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM435778(US10611751, Example 4 | 2-(2,6-dichlorophenyl)-1- ...)
Affinity DataEC50:  26nMAssay Description:Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  5.50E+3nMAssay Description:Induction of CYP3A4 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM435739(US10611751, Example 1 | 2-(2,6-dichlorophenyl)-1-(...)
Affinity DataEC50:  3.20E+3nMAssay Description:Induction of CYP3A4 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetD(1A) dopamine receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM435739(US10611751, Example 1 | 2-(2,6-dichlorophenyl)-1-(...)
Affinity DataEC50:  151nMAssay Description:Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetD(1B) dopamine receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM435739(US10611751, Example 1 | 2-(2,6-dichlorophenyl)-1-(...)
Affinity DataEC50:  480nMAssay Description:Positive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetD(1B) dopamine receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM435739(US10611751, Example 1 | 2-(2,6-dichlorophenyl)-1-(...)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM435739(US10611751, Example 1 | 2-(2,6-dichlorophenyl)-1-(...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human 5HT2bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM435739(US10611751, Example 1 | 2-(2,6-dichlorophenyl)-1-(...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human Cav2.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed