Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50016440
TargetPresenilin-1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28922((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)
Affinity DataEC50:  15nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 40 production by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPresenilin-1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28922((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)
Affinity DataEC50:  12nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 42 production by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataEC50:  35nMAssay Description:Modulation of amyloid beta 42 in human H4 cells expressing APP751 incubated overnight by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPresenilin-1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50533414(CHEMBL4436451)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as inhibition of NICD cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50594988(CHEMBL5192892)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of amyloid beta 42 (unknown origin) secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50594989(CHEMBL5206552)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of amyloid beta 42 (unknown origin) secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPresenilin-1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of gamma secretase derived from human Hela cell membrane assessed as reduction in amyloid beta (1 to 40) production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPresenilin-1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma-secretase in human H4 cells assessed as reduction in amyloid beta 42More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28922((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)
Affinity DataIC50: 15nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 40 production by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCathepsin D(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTrypsin(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed