Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50017662
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PDE4B2 (152 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603812(CHEMBL475165)
Affinity DataIC50: 74nMAssay Description:Inhibition of PDE4D expressed in human U-937 cells using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603817(CHEMBL5170835)
Affinity DataIC50: 180nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603818(CHEMBL5208713)
Affinity DataIC50: 400nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50: 490nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 820nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603822(CHEMBL5185722)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of PDE10A2 (449 to 770 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603832(CHEMBL5197754)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 4.25E+3nMAssay Description:Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603829(CHEMBL5205696)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603813(CHEMBL5201432)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603831(CHEMBL5171883)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603835(CHEMBL5204540)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603814(CHEMBL5202332)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603820(CHEMBL5178435)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603816(CHEMBL5200298)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603815(CHEMBL5200449)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603819(CHEMBL5203741)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM93217(Coumarin derivative, 2a)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603821(CHEMBL5193480)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603834(CHEMBL5181558)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603811(CHEMBL5171560)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of hERG by Q patch automated patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603824(CHEMBL5203549)
Affinity DataIC50: 6.84E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603833(CHEMBL5177463)
Affinity DataIC50: 7.24E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603823(CHEMBL5188747)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603830(CHEMBL5171119)
Affinity DataIC50: 9.88E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603825(CHEMBL5186911)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603836(CHEMBL5188271)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603826(CHEMBL5193320)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603828(CHEMBL5180007)
Affinity DataIC50: 3.72E+5nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation

Curated by ChEMBL
LigandPNGBDBM50603827(CHEMBL5190912)
Affinity DataIC50: 6.03E+5nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed