Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50015362
TargetLysosomal acid glucosylceramidase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585896(CHEMBL5085509)
Affinity DataEC50: >3.00E+5nMAssay Description:Inhibition of human recombinant GCase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate incubated for 20 mins by fluorescence-based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585896(CHEMBL5085509)
Affinity DataEC50:  4.40nMAssay Description:Inhibition of GCS in GBA mutant human fibroblasts assessed as reduction in glucosylceramide level incubated for 4 days by RapdiFire-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585893(CHEMBL5078078)
Affinity DataEC50:  7.60nMAssay Description:Inhibition of GCS in GBA mutant human fibroblasts assessed as reduction in glucosylceramide level incubated for 4 days by RapdiFire-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585896(CHEMBL5085509)
Affinity DataIC50: 15nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585892(CHEMBL5092141)
Affinity DataIC50: 17nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585900(CHEMBL5083428)
Affinity DataIC50: 19nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585893(CHEMBL5078078)
Affinity DataIC50: 31nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585894(CHEMBL5077442)
Affinity DataIC50: 40nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585899(CHEMBL5086168)
Affinity DataIC50: 45nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585897(CHEMBL5086523)
Affinity DataIC50: 49nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585889(CHEMBL5091974)
Affinity DataIC50: 49nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585893(CHEMBL5078078)
Affinity DataIC50: 51nMAssay Description:Inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585886(CHEMBL5076612)
Affinity DataIC50: 97nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585898(CHEMBL5091003)
Affinity DataIC50: 170nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585896(CHEMBL5085509)
Affinity DataIC50: 190nMAssay Description:Inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585893(CHEMBL5078078)
Affinity DataIC50: 310nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585891(CHEMBL5089984)
Affinity DataIC50: 630nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585890(CHEMBL5081829)
Affinity DataIC50: 700nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585887(CHEMBL5088946)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585878(CHEMBL5083924)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585877(CHEMBL5090560)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585876(CHEMBL5074066)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585895(CHEMBL5069925)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585885(CHEMBL5085654)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585880(CHEMBL5071935)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585888(CHEMBL5081824)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585896(CHEMBL5085509)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585875(CHEMBL5093384)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585884(CHEMBL5069574)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585883(CHEMBL5085627)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585882(CHEMBL5085407)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585881(CHEMBL5082608)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585879(CHEMBL5083606)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed