Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50016873
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597996(CHEMBL5196811)
Affinity DataKd:  160nMAssay Description:Inhibition of C-terminal His6-tagged Trypanosoma cruzi CYP51 expressed in Escherichia coli HMS174(DE3) assessed as dissociation constant by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597995(CHEMBL5189694)
Affinity DataKd:  24nMAssay Description:Displacement of [3H]-Eubricol from C-terminal His-tagged full-length Trypanosoma cruzi Tulahuen strain CYP51 expressed in Escherichia coli HMS174(DE3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen strain CYP51 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50114613((1E)-1-(3-bromophenyl)propan-1-one thiosemicarbazo...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Trypanosoma cruzi CruzaineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50295129(5-(2-Amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic ...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Trypanosoma cruzi CruzaineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597999(CHEMBL5198927)
Affinity DataIC50: 600nMAssay Description:Inhibition of Trypanosoma cruzi CruzaineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50181473(CHEMBL1397 | 4-(4-(4-(4-(((5R)-5-((1H-1,2,4-triazo...)
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen strain CYP51 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597993(Anethole trithione | Anethole Trithione | Anetholt...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Trypanosoma cruzi TIM expressed in Escherichia coli using glyceraldehyde 3-phosphate as substrate in presence of NADH/alphaGDPH measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597988(CHEMBL5192352)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi TIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597987(CHEMBL5170853)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi TIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50332795(3-(4-methylphenyl)-5-oxo-4,5-dihydro-1,2,4-thiadia...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of Trypanosoma cruzi TIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597990(CHEMBL3990589)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi TIM using glyceraldehyde 3-phosphate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597994(CHEMBL5172018)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Trypanosoma cruzi TIM expressed in Escherichia coli using glyceraldehyde 3-phosphate as substrate in presence of NADH/alphaGDPH measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597991(CHEMBL5198783)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of Trypanosoma cruzi TIM expressed in Escherichia coli using glyceraldehyde 3-phosphate as substrate preincubated for 2 hrs in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597998(CHEMBL5184910)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Trypanosoma cruzi CruzaineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597992(CHEMBL5169735)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of Trypanosoma cruzi TIM expressed in Escherichia coli using glyceraldehyde 3-phosphate as substrate preincubated for 2 hrs in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTriosephosphate isomerase, glycosomal(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597989(CHEMBL1161789)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi TIM using glyceraldehyde 3-phosphate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCruzipain(Trypanosoma cruzi)
Universidad De Navarra

Curated by ChEMBL
LigandPNGBDBM50597997(CHEMBL5181562)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of Trypanosoma cruzi Cruzaine using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured for 10 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed