Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50015389
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586147(CHEMBL5074631)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386094(N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexy...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586148(CHEMBL5091670)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386120(US10287305, Example 70 | N-((2R,3S)-1-acetyl-2-(((...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386128(N-(cis-1-acetyl-2-(((cis-4- isopropylcyclohexyl)ox...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386129(N-(cis-1-acetyl-2-(((cis-4- isopropylcyclohexyl)ox...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586149(CHEMBL5083834)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586150(CHEMBL5094264)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386170(N-(cis-1-acetyl-2-(((cis-4- methylcyclohexyl)oxy)m...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586146(CHEMBL5073349)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386065(US10287305, Example 333 | N-((2R,3S)-2-(((cis-4- p...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386208(N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386857(ethyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50: >1.40E+4nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586151(CHEMBL5084444)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586152(CHEMBL5079059)
Affinity DataEC50:  0.0680nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586146(CHEMBL5073349)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586147(CHEMBL5074631)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586148(CHEMBL5091670)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386120(US10287305, Example 70 | N-((2R,3S)-1-acetyl-2-(((...)
Affinity DataEC50:  330nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386128(N-(cis-1-acetyl-2-(((cis-4- isopropylcyclohexyl)ox...)
Affinity DataEC50:  940nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386129(N-(cis-1-acetyl-2-(((cis-4- isopropylcyclohexyl)ox...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586149(CHEMBL5083834)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586150(CHEMBL5094264)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386170(N-(cis-1-acetyl-2-(((cis-4- methylcyclohexyl)oxy)m...)
Affinity DataEC50:  3.70E+3nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386094(N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexy...)
Affinity DataEC50:  270nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386066(N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)o...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386065(US10287305, Example 333 | N-((2R,3S)-2-(((cis-4- p...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386208(N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  5.5nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386857(ethyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis-...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  0.290nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586151(CHEMBL5084444)
Affinity DataEC50:  570nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586152(CHEMBL5079059)
Affinity DataEC50:  0.180nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed