Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50016262
LigandPNGBDBM431867(US10550114, Compound 1a)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50459091(ABL-001 | ABL001 | ABL001-NX | Asciminib | NVP-ABL...)
Affinity DataKd:  0.450nMAssay Description:Binding affinity to BCR-ABL1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50453891(CHEMBL4214567)
Affinity DataIC50: 3nMAssay Description:Inhibition of human GST-fused EGFR T790M/C797S double mutant expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50593634(CHEMBL5169921)
Affinity DataIC50: 30nMAssay Description:Inhibition of human N-terminal His6 tagged ITK (354 to 620 residues) expressed in Sf9 insect cells incubated for 30 mins by time-resolved fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50507490(CHEMBL4468886)
Affinity DataIC50: 99nMAssay Description:Inhibition of C-terminal Prolink-peptide tagged TrkA (unknown origin) by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase WNK1(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human WNK1 (198 to 401 residues) using biotinylated STK3 as substrate incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataIC50: 360nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50593632(CHEMBL5201485)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant ERK5 incubated for 60 mins by TR-FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)