Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50017210
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600312(CHEMBL5189266)
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234969(n-(cyanomethyl)-4-(5-methyl-2-((4-(4-morpholinopip...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234969(n-(cyanomethyl)-4-(5-methyl-2-((4-(4-morpholinopip...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600312(CHEMBL5189266)
Affinity DataIC50: 3nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234968(4-(2-((4-(4-(6-acetyl-3,6-diazabicyclo[3.1.1]hepta...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234957(4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piper...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234957(4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piper...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234960(n-(cyanomethyl)-4-(2-((4-(4-(2-oxo-1-oxa-8-azaspir...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234946(n-(cyanomethyl)-4-(2-((4-(4-morpholinopiperidin-1-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234958(n-(cyanomethyl)-4-(2-((4-(4-(5-methyl-1,3,4-oxadia...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234954(4-(2-((4-(4-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234968(4-(2-((4-(4-(6-acetyl-3,6-diazabicyclo[3.1.1]hepta...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600312(CHEMBL5189266)
Affinity DataIC50: 9nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600306(CHEMBL5201856)
Affinity DataIC50: 10nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234960(n-(cyanomethyl)-4-(2-((4-(4-(2-oxo-1-oxa-8-azaspir...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234969(n-(cyanomethyl)-4-(5-methyl-2-((4-(4-morpholinopip...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234958(n-(cyanomethyl)-4-(2-((4-(4-(5-methyl-1,3,4-oxadia...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234946(n-(cyanomethyl)-4-(2-((4-(4-morpholinopiperidin-1-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234954(4-(2-((4-(4-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234973(n-(cyanomethyl)-4-(5-fluoro-2-((4-(4-morpholinopip...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234948(4-(2-((4-(4-(1h-1,2,4-triazol-1-yl)piperidin-1-yl)...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600308(CHEMBL5174885)
Affinity DataIC50: 18nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234948(4-(2-((4-(4-(1h-1,2,4-triazol-1-yl)piperidin-1-yl)...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600308(CHEMBL5174885)
Affinity DataIC50: 22nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600306(CHEMBL5201856)
Affinity DataIC50: 35nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234957(4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piper...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234958(n-(cyanomethyl)-4-(2-((4-(4-(5-methyl-1,3,4-oxadia...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234968(4-(2-((4-(4-(6-acetyl-3,6-diazabicyclo[3.1.1]hepta...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600307(CHEMBL5185244)
Affinity DataIC50: 52nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234960(n-(cyanomethyl)-4-(2-((4-(4-(2-oxo-1-oxa-8-azaspir...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600307(CHEMBL5185244)
Affinity DataIC50: 57nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234946(n-(cyanomethyl)-4-(2-((4-(4-morpholinopiperidin-1-...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234948(4-(2-((4-(4-(1h-1,2,4-triazol-1-yl)piperidin-1-yl)...)
Affinity DataIC50: 66nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234954(4-(2-((4-(4-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600307(CHEMBL5185244)
Affinity DataIC50: 97nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600308(CHEMBL5174885)
Affinity DataIC50: 102nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600306(CHEMBL5201856)
Affinity DataIC50: 125nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 134nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600309(CHEMBL5198976)
Affinity DataIC50: 500nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600311(CHEMBL5171066)
Affinity DataIC50: 500nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600309(CHEMBL5198976)
Affinity DataIC50: 500nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600311(CHEMBL5171066)
Affinity DataIC50: 500nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50600310(CHEMBL5175767)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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