Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50015737
TargetCatenin beta-1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50436058(PNU-74654 | CHEMBL254381 | US9738628, Compound PNU...)
Affinity DataKd:  450nMAssay Description:Binding affinity to beta catenin ARD (134 to 671 residues) (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to N-terminal FLAG tagged beta catenin alpha helix (H1 - 141 to 149 aa) of armadillo repeat domain (unknown origin) by STD/HSQC base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKd:  530nMAssay Description:Binding affinity to beta catenin ARD (142 to 686 residues) (unknown origin) assessed as dissociation constant by VP-ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50509781(CHEMBL4450852)
Affinity DataKd:  420nMAssay Description:Binding affinity to beta catenin (unknown origin) assessed as dissociation constant by VP-ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human PARG assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTranscription factor 4(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50556644(NSC-45382 | CHEMBL1214274)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of beta catenin/Tcf4 (8 to 30 reisdues) (unknown origin) incubated for 3 hrs by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50589223(CHEMBL5185515)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant GST tagged beta catenin ARD by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranscription factor 4(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50589224(CHEMBL5173483)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of beta catenin/Tcf4 (unknown origin) protein protein interaction measured after 24 hrs by TOP-flash luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranscription factor 4(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50094484(CHEMBL2323033 | CHEBI:3556 | US9284299, CGP049090 ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta catenin/recombinant GST tagged Tcf4 protein protein interaction in human HCT-116 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranscription factor 4(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50589220(CHEMBL3890384)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta catenin/recombinant GST tagged Tcf4 protein protein interaction in human HCT-116 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTranscription factor 4(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50589221(CHEMBL5192638)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta catenin/recombinant GST tagged Tcf4 protein protein interaction in human HCT-116 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50589222(CHEBI:60370 | (-)-(r)-etodolac | (-)-etodolac | Et...)
Affinity DataIC50: 6.83E+5nMAssay Description:Inhibition of beta catenin in HEK293 cells by TOPflash luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity to N-terminal FLAG tagged beta catenin (134 to 671 residues)/FLAG tagged BCL9 domain 2 (343 to 396 residues) (unknown origin) protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity to beta catenin ARD (142 to 686 residues) (unknown origin) assessed as inhibition constant by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed