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Report error Found 98 Enz. Inhib. hit(s) with all data for entry = 50016323
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594270(CHEMBL5201988)
Affinity DataKd:  1.62E+5nMAssay Description:Binding affinity to CM5 sensor chip immobilized human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594269(CHEMBL5187195)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to CM5 sensor chip immobilized human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594270(CHEMBL5201988)
Affinity DataEC50:  2.71E+4nMAssay Description:Inhibition of human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594269(CHEMBL5187195)
Affinity DataEC50:  2.61E+4nMAssay Description:Inhibition of human PARP14 MD2 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataKd:  0.220nMAssay Description:Binding affinity to PARP7 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PARP7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM434315(US10562891, Example 235 | US11008308, Example 235)
Affinity DataIC50: 3nMAssay Description:Inhibition of PARP14 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594259(CHEMBL5180081)
Affinity DataIC50: 10nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594012(CHEMBL5191676)
Affinity DataIC50: 14nMAssay Description:Inhibition of PARP11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 17nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM434254(US10562891, Example 176 | US11008308, Example 176)
Affinity DataIC50: 19nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 37nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594258(CHEMBL5178541)
Affinity DataIC50: 76nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594250(CHEMBL5207717)
Affinity DataIC50: 99nMAssay Description:Inhibition of PARP11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594250(CHEMBL5207717)
Affinity DataIC50: 156nMAssay Description:Inhibition of PARP10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594261(CHEMBL5190289)
Affinity DataIC50: 200nMAssay Description:Inhibition of biotinylated recombinant human PARP15 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM434101(US10562891, Example 23 | US11008308, Example 23)
Affinity DataIC50: 300nMAssay Description:Inhibition of PARP14 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594256(CHEMBL5196898)
Affinity DataIC50: 310nMAssay Description:Displacement of [3H]NAD+ from GST-tagged PARP14 (unknown origin) incubated for 210 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50: 330nMAssay Description:Inhibition of PARP10 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594267(CHEMBL5189477)
Affinity DataIC50: 362nMAssay Description:Inhibition of PARP16 (unknown origin) using IRE-1 as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594266(CHEMBL5172255)
Affinity DataIC50: 427nMAssay Description:Inhibition of PARP16 (unknown origin) using IRE-1 as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50272952(CHEMBL4126054)
Affinity DataIC50: 480nMAssay Description:Inhibition of C-terminal his-tagged human PARP10 expressed in Escherichia coli Rosette2 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594244(CHEMBL5205408)
Affinity DataIC50: 490nMAssay Description:Inhibition of PARP14 (unknown origin) expressed in bacterial expression system using histone substrate incubated for 60 mins by chemiluminescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594250(CHEMBL5207717)
Affinity DataIC50: 496nMAssay Description:Inhibition of PARP15 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594262(CHEMBL5187652)
Affinity DataIC50: 510nMAssay Description:Inhibition of biotinylated recombinant human PARP15 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594249(CHEMBL5186007)
Affinity DataIC50: 550nMAssay Description:Inhibition of PARP11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594255(CHEMBL5199759)
Affinity DataIC50: 580nMAssay Description:Displacement of [3H]NAD+ from GST-tagged PARP14 (unknown origin) incubated for 210 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594257(CHEMBL5191979)
Affinity DataIC50: 610nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50461016(CHEMBL4226393)
Affinity DataIC50: 710nMAssay Description:Inhibition of PARP14 MD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594245(CHEMBL5186947)
Affinity DataIC50: 760nMAssay Description:Inhibition of PARP14 (unknown origin) expressed in bacterial expression system using histone substrate incubated for 60 mins by chemiluminescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594246(CHEMBL5181342)
Affinity DataIC50: 770nMAssay Description:Inhibition of PARP14 (unknown origin) expressed in bacterial expression system using histone substrate incubated for 60 mins by chemiluminescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50590269(CHEMBL5187963)
Affinity DataIC50: 800nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594250(CHEMBL5207717)
Affinity DataIC50: 917nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594263(CHEMBL5200663)
Affinity DataIC50: 970nMAssay Description:Inhibition of biotinylated recombinant human PARP15 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594260(CHEMBL5177845)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP14 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50590269(CHEMBL5187963)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594254(CHEMBL5197543)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of PARP14 (unknown origin) incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50272952(CHEMBL4126054)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of N-terminal his-tagged human PARP15 expressed in Escherichia coli Rosette2 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50272952(CHEMBL4126054)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of N-terminal his-tagged human PARP2 expressed in Escherichia coli Rosette2 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594012(CHEMBL5191676)
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594268(CHEMBL5178746)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant human PARP3 using IRE-1 as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594266(CHEMBL5172255)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human PARP3 using IRE-1 as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594247(CHEMBL5184823)
Affinity DataIC50: 3.64E+3nMAssay Description:Inhibition of C-terminal his-tagged human PARP10 expressed in Escherichia coli Rosette2 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594253(CHEMBL5189956)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of PARP14 (unknown origin) incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50553475(CHEMBL4741195)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of PARP10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50272952(CHEMBL4126054)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of N-terminal his-tagged human TNKS2 expressed in Escherichia coli Rosette2 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50594249(CHEMBL5186007)
Affinity DataIC50: 8.55E+3nMAssay Description:Inhibition of PARP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
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