Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50017934
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetVoltage-dependent L-type calcium channel subunit beta-2(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50101971(CHEBI:7575 | BAY-E-9736 | Nimodipine | Nimotop)
Affinity DataIC50: 30nMAssay Description:Inhibition of human alpha1c/beta2a/alpha2delta1 Cav1.2 expressed in HEK293 cells assessed as Ca2+ current at -80 mV holding potential by patch clamp ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606301(CHEMBL5183406)
Affinity DataIC50: 73nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606304(CHEMBL5181197)
Affinity DataIC50: 88nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 145nMAssay Description:Inhibition of PDE1A (142 to 552 residues) (unknown origin) expressed in Escherichia coli BL21 measured for 15 mins by liquid scintillation counter me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606305(CHEMBL5178800)
Affinity DataIC50: 178nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606306(CHEMBL5208410)
Affinity DataIC50: 189nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606303(CHEMBL5199616)
Affinity DataIC50: 194nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606308(CHEMBL5193756)
Affinity DataIC50: 285nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606302(CHEMBL5176107)
Affinity DataIC50: 297nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 354nMAssay Description:Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 619nMAssay Description:Inhibition of PDE4B2 (152 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 measured for 15 mins by liquid scintillation counter m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 948nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 [3H]-cAMP as substrate measured for 15 mins by liquid s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50101971(CHEBI:7575 | BAY-E-9736 | Nimodipine | Nimotop)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of PDE10A (449 to 770 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP as substrate measured for 15 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PDE7A1 (130-482 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP as substrate measured for 15 mins by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21 [3H]-cGMP as substrate measured for 15 mins by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50237611(CHEBI:7582 | BAY-E-5009 | Baypress | Nitrendipine)
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606299(CHEMBL5194762)
Affinity DataIC50: 2.89E+3nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606298(CHEMBL5204506)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes at 25 uM in the presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 25 uM in the presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606300(CHEMBL5174670)
Affinity DataIC50: 7.01E+3nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50101971(CHEBI:7575 | BAY-E-9736 | Nimodipine | Nimotop)
Affinity DataIC50: 7.15E+3nMAssay Description:Inhibition of PDE4D (unknown origin) expressed in Escherichia coli BL21 [3H]-cAMP as substrate measured for 15 mins by liquid scintillation counter m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50101817(CHEBI:7565 | Adalat | Adalat Cc | Afeditab Cr | BA...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP as substrate measured for 15 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP as substrate measured for 15 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606307(CHEMBL5180169)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of hERG ion channel expressed in CHO cells by automated patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed