Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50019798
TargetATP-dependent translocase ABCB1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50468251(CHEMBL4287524)
Affinity DataEC50:  3.50E+4nMAssay Description:Inhibition of ABCB1 efflux pump in human LS180 cells using Rh123 as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50468250(CHEMBL4286029)
Affinity DataEC50:  3.50E+4nMAssay Description:Inhibition of ABCB1 efflux pump in human LS180 cells using Rh123 as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50: 25nMAssay Description:Inhibition of ABCB1 in human HEK293 cells in the presence of doxorubicinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataIC50: 68nMAssay Description:Inhibition of ABCB1 in multi-drug resistance human HL-60 cells assessed as increase in daunorubicin accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 504nMAssay Description:Inhibition of ABCB1 in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50410873(CHEMBL105360 | CHEBI:65737)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of P-gp1 efflux in human Flp-In-293 cells using rhodamine as substrate assessed as increase in intracellular accumulation of rhodamine 123...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50410873(CHEMBL105360 | CHEBI:65737)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of P-gp1 efflux in human Flp-In-293 cells using calcein-AM as substrate assessed as increase in intracellular accumulation of calcein-AM p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50468250(CHEMBL4286029)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of VEGFR1 (unknown origin) using KKKSPGEYVNIEFG as substrate at 2 uM by [gamma-33P]ATP based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50468251(CHEMBL4287524)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of VEGFR1 (unknown origin) using KKKSPGEYVNIEFG as substrate at 2 uM by [gamma-33P]ATP based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataIC50: 4.44E+3nMAssay Description:Inhibition of ABCG2 efflux pump in multi-drug resistance human HL-60 cells assessed as reversal of daunorubicin sensitivityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed