Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50016812
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597440(CHEMBL5170297)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataEC50:  79nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597431(CHEMBL5198776)
Affinity DataEC50:  180nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597432(CHEMBL5173240)
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597433(CHEMBL5172269)
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597434(CHEMBL5170656)
Affinity DataEC50:  450nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597435(CHEMBL5196694)
Affinity DataEC50:  190nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM20180((1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5S)-5-hydroxy-6...)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597437(CHEMBL5200422)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597438(CHEMBL5198675)
Affinity DataEC50:  81nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597439(CHEMBL5197305)
Affinity DataEC50:  23nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597436(CHEMBL5189622)
Affinity DataEC50:  49nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597441(CHEMBL5174404)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597442(CHEMBL5178963)
Affinity DataEC50:  590nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597443(CHEMBL5175389)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597444(CHEMBL5170022)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597445(CHEMBL5204245)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597446(CHEMBL5181802)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM521682(US11149054, Compound 9062)
Affinity DataEC50:  250nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597447(CHEMBL5178281)
Affinity DataEC50:  1.50E+3nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2C receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataEC50:  430nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2D receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597431(CHEMBL5198776)
Affinity DataEC50:  310nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50528615(CHEMBL4448829)
Affinity DataEC50:  480nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50528608(CHEMBL4555750)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataEC50:  86nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50528615(CHEMBL4448829)
Affinity DataEC50:  38nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597432(CHEMBL5173240)
Affinity DataEC50:  55nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597433(CHEMBL5172269)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597434(CHEMBL5170656)
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597435(CHEMBL5196694)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597436(CHEMBL5189622)
Affinity DataEC50:  74nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597437(CHEMBL5200422)
Affinity DataEC50:  420nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597439(CHEMBL5197305)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597447(CHEMBL5178281)
Affinity DataEC50:  2.20E+3nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM521682(US11149054, Compound 9062)
Affinity DataEC50:  93nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597446(CHEMBL5181802)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597445(CHEMBL5204245)
Affinity DataEC50:  180nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597444(CHEMBL5170022)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597442(CHEMBL5178963)
Affinity DataEC50:  220nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597438(CHEMBL5198675)
Affinity DataEC50:  120nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597440(CHEMBL5170297)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597441(CHEMBL5174404)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597443(CHEMBL5175389)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NaV1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of KCNQ1/MINK (unknown origin) by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CaV1.2 (unknown origin) by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(Dalzanemdor | DALZANEMDOR)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kv1.5 (unknown origin) by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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