Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with all data for entry = 50015756
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332847(US10196390, Compound I-136)
Affinity DataIC50: 47nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332847(US10196390, Compound I-136)
Affinity DataIC50: 64nMAssay Description:Inhibition of Jak1/Jak3 in human PBMC assessed as inhibition of IL2-stimulated phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332858(US10196390, Compound I-147)
Affinity DataIC50: 82nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332893(US10196390, Compound I-182)
Affinity DataIC50: 83nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332959(US10196390, Compound I-248)
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332882(US10196390, Compound I-171 | US10336752, Compound ...)
Affinity DataIC50: 98nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 110nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Jak1/Jak3 in human PBMC assessed as inhibition of IL2-stimulated phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332816(US10196390, Compound I-88)
Affinity DataIC50: 180nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM490686(US10968236, Compound I-14)
Affinity DataIC50: 240nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 240nMAssay Description:Inhibition of Jak1/Jak3 in human PBMC assessed as inhibition of IL2-stimulated phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332847(US10196390, Compound I-136)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Jak2 in human PBMC assessed as inhibition of GM-CSF-stimulated phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332807(US10196390, Compound I-80)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Jak2 in human PBMC assessed as inhibition of GM-CSF-stimulated phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of Jak2 in human PBMC assessed as inhibition of GM-CSF-stimulated phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2A6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERG measured by patchclamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332992(US10196390, Compound I-281)
Affinity DataKi:  0.0510nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332893(US10196390, Compound I-182)
Affinity DataKi:  0.0810nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332847(US10196390, Compound I-136)
Affinity DataKi:  0.150nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589369(CHEMBL5197513)
Affinity DataKi:  0.190nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332858(US10196390, Compound I-147)
Affinity DataKi:  0.210nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332993(US10196390, Compound I-282)
Affinity DataKi:  0.230nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM490686(US10968236, Compound I-14)
Affinity DataKi:  0.240nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM490686(US10968236, Compound I-14)
Affinity DataKi:  0.240nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332959(US10196390, Compound I-248)
Affinity DataKi:  0.340nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332882(US10196390, Compound I-171 | US10336752, Compound ...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589370(CHEMBL5182922)
Affinity DataKi:  0.370nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM406663(US10336752, Compound 2 | US10336752, Compound 4 | ...)
Affinity DataKi:  0.510nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332923(US10196390, Compound I-212)
Affinity DataKi:  0.830nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589368(CHEMBL5182121)
Affinity DataKi:  0.850nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589368(CHEMBL5182121)
Affinity DataKi:  0.850nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332805(US10196390, Compound I-78)
Affinity DataKi:  0.970nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332857(US10196390, Compound I-146)
Affinity DataKi:  1.10nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332816(US10196390, Compound I-88)
Affinity DataKi:  1.30nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332864(US10196390, Compound I-153)
Affinity DataKi:  1.60nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332864(US10196390, Compound I-153)
Affinity DataKi:  1.60nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332794(US10196390, Compound I-67)
Affinity DataKi:  1.80nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50589366(CHEMBL5203504)
Affinity DataKi:  3.30nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
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