Compile Data Set for Download or QSAR
Report error Found 128 Enz. Inhib. hit(s) with all data for entry = 50020111
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626248(CHEMBL106871)
Affinity DataKd:  1nMAssay Description:Inhibition of human nNOS assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50226527(N-[3-(aminomethyl)benzyl]ethanimidamide | N-(3-Ami...)
Affinity DataKd:  7nMAssay Description:Inhibition of recombinant human iNOS assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversion in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626248(CHEMBL106871)
Affinity DataIC50: 1nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50418849(CHEMBL1738840)
Affinity DataIC50: 86nMAssay Description:Inhibition of human iNOS transfected in baculovirus infected Sf9 cells assessed as reduction of [3H]L-arginine conversion to [3H]L-citrulline by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 86nMAssay Description:Inhibition of full length recombinant human arginase 1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50148162(Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626250(CHEMBL1221704)
Affinity DataIC50: 400nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50072297(5-Acetimidoylamino-2-(S)-amino-pentanoic acid | CH...)
Affinity DataIC50: 800nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626250(CHEMBL1221704)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50225106(NG-nitroarginine | 2-Amino-5-(N'-nitro-guanidino)-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of rat brain nNOS expressed in baculovirus infected sf9 cells measured after 72 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged thrombin-cleavable human arginase 1 expressed in Escherichia coli DE3 cells measured after 90 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human arginase 1 measured after 60 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50086467((S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-b...)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of human iNOS expressed in baculovirus infected Spodoptera frugiperda cell using L-arginine as substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Mouse)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50072297(5-Acetimidoylamino-2-(S)-amino-pentanoic acid | CH...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of mouse nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50519933(CHEMBL4444007)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50063300(l-NIL | CHEMBL1744034 | (L-N6-1-iminoethyl)lysine ...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human DDAH1 using SMTC as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626249(CHEMBL5422496)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240715((S)-2-Amino-5-but-3-enimidoylamino-pentanoic acid ...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50418849(CHEMBL1738840)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human nNOS transfected in baculovirus infected Sf9 cells assessed as reduction of [3H]L-arginine conversion to [3H]L-citrulline by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626259(CHEMBL5437726)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-2, mitochondrial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626255(CHEMBL5426729)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of arginase 2 in human LNCaP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50148162(Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240621(N-hydroxyhydrazinecarboximidamide | 1-amino-3-hydr...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of bovine eNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240621(N-hydroxyhydrazinecarboximidamide | 1-amino-3-hydr...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of mouse iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626258(CHEMBL5410984)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626251(CHEMBL1231428)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of iNOS (unknown origin) assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-1(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Sprague-Dawley rat liver arginase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50242402(4-Hydroxynonenal | 4-hydroxy-2-nonenal | CHEMBL454...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human DDAH1 expressed in Escherichia coli measured after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50070208(CHEBI:6375 | A-65006 | AG-1749 | Lansoprazole | Pr...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of recombinant human DDAH1 by HTS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50254452(N-omega-propargyl-L-arginine | CHEMBL197234)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50429750(CAFFEIC ACID PHENETHYL AMIDE)
Affinity DataIC50: 6.03E+4nMAssay Description:Inhibition of human arginase 1 measured after 60 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50063300(l-NIL | CHEMBL1744034 | (L-N6-1-iminoethyl)lysine ...)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50098937(CHEMBL7890 | CHEMBL1256014 | methyl (2S)-2-amino-5...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of rat brain nNOS expressed in baculovirus-infected Sf9 cells Escherichia coli assessed as reduction of [3H]-arginine to [3H]-citrulline c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50255074(N5-(1-iminobutyl)-L-ornithine | (S)-2-Amino-5-buty...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50254449(N5-(1-iminopent-3-enyl)-L-ornithine | CHEMBL456882)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626261(CHEMBL5434286)
Affinity DataIC50: 1.31E+5nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50063300(l-NIL | CHEMBL1744034 | (L-N6-1-iminoethyl)lysine ...)
Affinity DataIC50: 1.38E+5nMAssay Description:Inhibition of human eNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626249(CHEMBL5422496)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetArginase-1(Rat)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50230418(N-OMEGA-HYDROXY-L-ARGININE | Nomega-hydroxy-L-argi...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of Sprague-Dawley rat liver arginase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50418849(CHEMBL1738840)
Affinity DataIC50: 1.62E+5nMAssay Description:Inhibition of human eNOS transfected in baculovirus infected Sf9 cells assessed as reduction of [3H]L-arginine conversion to [3H]L-citrulline by scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50086467((S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-b...)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of human nNOS expressed in baculovirus infected Spodoptera frugiperda cell using L-arginine as substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50086467((S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-b...)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of human eNOS expressed in baculovirus infected Spodoptera frugiperda cell using L-arginine as substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50254451(N-omega-(but-3-enyl)-L-arginine | CHEMBL106423)
Affinity DataIC50: 1.89E+5nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240714((2S)-5-{[(allylamino)(iminio)methyl]amino}-2-ammon...)
Affinity DataIC50: 2.07E+5nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626260(CHEMBL5438148)
Affinity DataIC50: 2.30E+5nMAssay Description:Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate preincubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626257(CHEMBL364952)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human DDAH1 using [14C]-L-NMMA as substrate assessed as reduction in [14C]-citrulline conversion measured after 1 hrs by by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240716(Nomega-propyl-L-arginine | N-omega-propyl-L-argini...)
Affinity DataIC50: 2.83E+5nMAssay Description:Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626251(CHEMBL1231428)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of nNOS (unknown origin) assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626267(CHEMBL5433812)
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of human DDAH1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
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