Compile Data Set for Download or QSAR
Report error Found 132 Enz. Inhib. hit(s) with all data for entry = 50016195
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50083351(4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phen...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593147(CHEMBL5203777)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593148(CHEMBL5204934)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50009307(Di-o-tolylguanidine | DITOLYLGUANIDINE)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593148(CHEMBL5204934)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50009307(Di-o-tolylguanidine | DITOLYLGUANIDINE)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50083351(4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phen...)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593146(CHEMBL5207817)
Affinity DataKi:  109nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593145(CHEMBL5192784)
Affinity DataKi:  115nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593150(CHEMBL5205006)
Affinity DataKi:  121nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50083351(4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phen...)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593140(CHEMBL5171428)
Affinity DataKi:  147nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593145(CHEMBL5192784)
Affinity DataKi:  158nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataKi:  184nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593152(CHEMBL5176580)
Affinity DataKi:  187nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593140(CHEMBL5171428)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593150(CHEMBL5205006)
Affinity DataKi:  202nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593141(CHEMBL5192987)
Affinity DataKi:  204nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593147(CHEMBL5203777)
Affinity DataKi:  213nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593141(CHEMBL5192987)
Affinity DataKi:  229nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593147(CHEMBL5203777)
Affinity DataKi:  233nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593158(CHEMBL5172256)
Affinity DataKi:  238nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593145(CHEMBL5192784)
Affinity DataKi:  238nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593158(CHEMBL5172256)
Affinity DataKi:  238nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593150(CHEMBL5205006)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593148(CHEMBL5204934)
Affinity DataIC50: 340nMAssay Description:Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593143(CHEMBL5194197)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593146(CHEMBL5207817)
Affinity DataKi:  457nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593140(CHEMBL5171428)
Affinity DataKi:  476nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593142(CHEMBL5207906)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593155(CHEMBL5206663)
Affinity DataKi:  505nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593148(CHEMBL5204934)
Affinity DataKi:  519nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593138(CHEMBL5185552)
Affinity DataKi:  543nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593143(CHEMBL5194197)
Affinity DataKi:  570nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593144(CHEMBL5203299)
Affinity DataKi:  575nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593150(CHEMBL5205006)
Affinity DataKi:  809nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593140(CHEMBL5171428)
Affinity DataIC50: 810nMAssay Description:Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593139(CHEMBL5183248)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593138(CHEMBL5185552)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593142(CHEMBL5207906)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593144(CHEMBL5203299)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593149(CHEMBL5198839)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593151(CHEMBL5178466)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593152(CHEMBL5176580)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593151(CHEMBL5178466)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593153(CHEMBL5177298)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
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