Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50019935
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM15581(US8633208, Clorgyline | [3-(2,4-dichlorophenoxy)pr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human MAO-A using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM19187(CHEMBL396778 | (2S)-2-[({4-[(3-fluorophenyl)methox...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM15579(US8633208, Deprenyl | CHEMBL972 | L-Deprenyl | SLG...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 53nMAssay Description:Inhibition of S-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataIC50: 147nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624835(Ls-104 | Tyrene cr-4 | LS-104)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624836(CHEMBL5400279)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624839(CHEMBL5436270)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624833(CHEMBL5410682)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624838(CHEMBL5418340)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624837(CHEMBL5422642)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50381224(CHEMBL2018554)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM15581(US8633208, Clorgyline | [3-(2,4-dichlorophenoxy)pr...)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624834(CHEMBL5421285)
Affinity DataIC50: 2.41E+3nMAssay Description:Inhibition of MB-COMT in rat brain homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50381224(CHEMBL2018554)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624833(CHEMBL5410682)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624839(CHEMBL5436270)
Affinity DataIC50: 3.64E+3nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibition of human MAO-A using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624834(CHEMBL5421285)
Affinity DataIC50: 3.74E+3nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50381224(CHEMBL2018554)
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624836(CHEMBL5400279)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624838(CHEMBL5418340)
Affinity DataIC50: 4.27E+3nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624833(CHEMBL5410682)
Affinity DataIC50: 4.27E+3nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624836(CHEMBL5400279)
Affinity DataIC50: 4.38E+3nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624834(CHEMBL5421285)
Affinity DataIC50: 4.55E+3nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCatechol O-methyltransferase(Rat)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50624837(CHEMBL5422642)
Affinity DataIC50: 6.13E+3nMAssay Description:Inhibition of MB-COMT in rat liver homogenates using adrenaline as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM15579(US8633208, Deprenyl | CHEMBL972 | L-Deprenyl | SLG...)
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of human MAO-A using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed