Compile Data Set for Download or QSAR
Report error Found 129 Enz. Inhib. hit(s) with all data for entry = 50015992
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKd:  0.0776nMAssay Description:Binding affinity to Nluc-A3R (unknown origin) expressed in HEK293 cells by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataIC50: 0.0977nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKd:  0.0977nMAssay Description:Binding affinity to wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as dissociation constant by by Schild analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591169(CHEMBL5201810)
Affinity DataKi:  0.115nMAssay Description:Binding affinity to wild type A3R (unknown origin) expressed in CHO-K1 cells assessed as equilibrium binding affinity constant by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591172(CHEMBL5178790)
Affinity DataKd:  0.460nMAssay Description:Binding affinity to human adenosine A3R expressed in CHO cells membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM85618(J1.251.181G | CHEMBL302765 | MRE 3008F20)
Affinity DataKd:  0.550nMAssay Description:Binding affinity to adenosine A3R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataIC50: 0.933nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591171(CHEMBL5174600)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50004577(CHEMBL105100 | 8-Cyclopentyl-3-propyl-3,7-dihydro-...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human adenosine A1R expressed in CHO cells membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to Nluc-A1R (unknown origin) expressed in HEK293 cells by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591163(CHEMBL3929143)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591157(CHEMBL5187501)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591168(CHEMBL5180010)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591167(CHEMBL5189274)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591159(CHEMBL3927012)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591162(CHEMBL3929812)
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591169(CHEMBL5201810)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591160(CHEMBL5173159)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to A1R L250 6.51A mutant (unknown origin) by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591160(CHEMBL5173159)
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591165(CHEMBL5185003)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591171(CHEMBL5174600)
Affinity DataIC50: 4.30nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKi:  4.40nMAssay Description:Binding affinity to wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as equilibrium binding affinity constant by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50150074(2-Amino-4-(4-hydroxy-phenyl)-6-(1H-imidazol-2-ylme...)
Affinity DataKd:  4.60nMAssay Description:Displacement of [3H]-DPCPX from human adenosine A1R expressed in CHO cells membrane incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591167(CHEMBL5189274)
Affinity DataIC50: 4.70nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591164(CHEMBL5196781)
Affinity DataIC50: 4.90nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591159(CHEMBL3927012)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591170(CHEMBL5186062)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591163(CHEMBL3929143)
Affinity DataIC50: 5.10nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591170(CHEMBL5186062)
Affinity DataIC50: 6.80nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591169(CHEMBL5201810)
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591165(CHEMBL5185003)
Affinity DataIC50: 7.20nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKd:  7.90nMAssay Description:Binding affinity to A1R S267 7.32A mutant (unknown origin) in by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591166(CHEMBL5189470)
Affinity DataIC50: 8.90nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataKd:  9.10nMAssay Description:Binding affinity to A1R H251 6.52A mutant (unknown origin) by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50240839(CHEMBL4062581)
Affinity DataKd:  9.10nMAssay Description:Binding affinity to N-terminal Nano-luc tagged human adenosine A3R expressed in HEK293 cells membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to A1R H251 6.52A mutant (unknown origin) by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to wild type A3R (unknown origin) expressed in CHO-K1 cells assessed as equilibrium binding affinity constant by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKd:  10nMAssay Description:Binding affinity to Nluc-A3R (unknown origin) expressed in HEK293 cells by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591157(CHEMBL5187501)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591162(CHEMBL3929812)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591160(CHEMBL5173159)
Affinity DataKi:  12nMAssay Description:Binding affinity to wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as equilibrium binding affinity constant by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591168(CHEMBL5180010)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591166(CHEMBL5189470)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591161(CHEMBL5180268)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKd:  13nMAssay Description:Binding affinity to wild type A1R (unknown origin) by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591158(CHEMBL5181728)
Affinity DataKd:  13nMAssay Description:Binding affinity to wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as dissociation constant by by Schild analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50591160(CHEMBL5173159)
Affinity DataKd:  14nMAssay Description:Binding affinity to Nluc-A1R (unknown origin) expressed in HEK293 cells by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKd:  16nMAssay Description:Binding affinity to Nluc-A1R (unknown origin) expressed in HEK293 cells by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
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