Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 50016206
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593226(CHEMBL5184760)
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593214(CHEMBL5189574)
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593204(CHEMBL5173979)
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593219(CHEMBL5202945)
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593216(CHEMBL5183324)
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593215(CHEMBL5184539)
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593213(CHEMBL5180839)
Affinity DataIC50: 5nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593212(CHEMBL5207479)
Affinity DataIC50: 5nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50453891(CHEMBL4214567)
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593225(CHEMBL5193772)
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593222(CHEMBL5208056)
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593210(CHEMBL5172668)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593207(CHEMBL5189114)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593217(CHEMBL5180289)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593211(CHEMBL5187250)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593223(CHEMBL5193594)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593223(CHEMBL5193594)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR L858R/T790M mutant expressed in human NCI-H1975 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593224(CHEMBL5170519)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593218(CHEMBL5203543)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR L858R/T790M mutant expressed in human NCI-H1975 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593213(CHEMBL5180839)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593216(CHEMBL5183324)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593215(CHEMBL5184539)
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593219(CHEMBL5202945)
Affinity DataIC50: 15nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593203(CHEMBL5203388)
Affinity DataIC50: 16nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 16nMAssay Description:Inhibition of EGFR L858R mutant expressed in human NCI-H3255 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593209(CHEMBL5198433)
Affinity DataIC50: 16nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 17nMAssay Description:Inhibition of wild type EGFR expressed in human NCI-H2073 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593220(CHEMBL5207152)
Affinity DataIC50: 17nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593222(CHEMBL5208056)
Affinity DataIC50: 17nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593205(CHEMBL5173986)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593227(CHEMBL5177023)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593224(CHEMBL5170519)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593218(CHEMBL5203543)
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593221(CHEMBL5201725)
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593202(CHEMBL5195669)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593226(CHEMBL5184760)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593214(CHEMBL5189574)
Affinity DataIC50: 26nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593220(CHEMBL5207152)
Affinity DataIC50: 30nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of EGFR L858R/T790M mutant expressed in human NCI-H1975 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593221(CHEMBL5201725)
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593212(CHEMBL5207479)
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of EGFR L858R mutant expressed in human NCI-H3255 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 40nMAssay Description:Inhibition of EGFR L858R mutant expressed in human NCI-H3255 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593210(CHEMBL5172668)
Affinity DataIC50: 54nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50593217(CHEMBL5180289)
Affinity DataIC50: 91nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 92nMAssay Description:Inhibition of wild type EGFR expressed in human A-431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
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