Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50019499
TargetCatenin beta-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50589362(CHEMBL5181203)
Affinity DataKd:  5.80E+5nMAssay Description:Binding affinity to His-tagged beta-Catenin (134 to 668 residues) (unknown origin) assessed as dissociation constant by surface plasmon resonance ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCatenin beta-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50436058(PNU-74654 | CHEMBL254381 | US9738628, Compound PNU...)
Affinity DataKd:  450nMAssay Description:Binding affinity to beta-Catenin (unknown origin) assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCatenin beta-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619764(CHEMBL5430034)
Affinity DataKd:  550nMAssay Description:Binding affinity to full length His-tagged human beta-Catenin assessed as dissociation constant by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCatenin beta-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619761(CHEMBL4115972)
Affinity DataKd:  330nMAssay Description:Binding affinity to wild type beta-Catenin (unknown origin) assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCatenin beta-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKd:  531nMAssay Description:Displacement of biotinylated TCF4 from wild type beta-Catenin (unknown origin) assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCatenin beta-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014148(CHEMBL3260853)
Affinity DataKd:  418nMAssay Description:Binding affinity to beta-Catenin (unknown origin) assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619755(CHEMBL5274107)
Affinity DataIC50: 150nMAssay Description:Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619763(CHEMBL5436013)
Affinity DataIC50: 530nMAssay Description:Inhibition of beta-Catenin (301 to 670 residues)/TCF4 protein-protein interaction in human HCT-116 cells incubated for 20 hrs by TOPFLASH luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619762(CHEMBL5189621)
Affinity DataIC50: 583nMAssay Description:Inhibition of beta-Catenin (301 to 670 residues)/TCF4 protein-protein interaction in human HCT-116 cells incubated for 20 hrs by TOPFLASH luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619760(CHEMBL2397074)
Affinity DataIC50: 640nMAssay Description:Inhibition of human beta-Catenin/GST-tagged TCF4 (unknown origin) protein-protein interaction incubated for 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM32102(cid_66541 | 1,6-dimethylpyrimido[5,4-e][1,2,4]tria...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human beta-Catenin/GST-tagged TCF4 (unknown origin) protein-protein interaction incubated for 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50589223(CHEMBL5185515)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of human GST-tagged beta-Catenin/human His-tagged N-terminal biotinylated TCF4 (8 to 53 residues) protein-protein interaction by AlphaScre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556644(NSC-45382 | CHEMBL1214274)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of beta-Catenin/FITC-labeled TCF4 (8 to 30 residues) (unknown origin) protein-protein interaction incubated for 3 hrs by fluorescence pola...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50589223(CHEMBL5185515)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of human GST-tagged beta-Catenin/human His-tagged N-terminal biotinylated TCF4 (8 to 53 residues) protein-protein interaction by ELISA ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50158807(3-butyryl-1,8-dihydroxy-2-methylphenanthrene-9,10-...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human beta-Catenin/GST-tagged TCF4 (unknown origin) protein-protein interaction incubated for 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619756(CHEMBL5417142)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of beta-Catenin/TCF4 protein-protein interaction in human Hep3B cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619756(CHEMBL5417142)
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of beta-Catenin/TCF4 protein-protein interaction in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619756(CHEMBL5417142)
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of beta-Catenin/TCF4 protein-protein interaction in human Huh-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50468575(CHEMBL2312139)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interaction by TOPFLASH reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50500850(CHEMBL261214)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human beta-Catenin/GST-tagged TCF4 (unknown origin) protein-protein interaction incubated for 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM430647(Salinomycin)
Affinity DataIC50: 3.86E+3nMAssay Description:Inhibition of beta-Catenin/TCF4 protein-protein interaction in human HEK293T cells incubated for 24 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619759(CHEMBL5397220)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human beta-Catenin/GST-tagged TCF4 (unknown origin) protein-protein interaction incubated for 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50094484(CHEMBL2323033 | CHEBI:3556 | US9284299, CGP049090 ...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human beta-Catenin/GST-tagged TCF4 (unknown origin) protein-protein interaction incubated for 2 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619758(CHEMBL5432489)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of beta-Catenin/TCF4 protein-protein interaction in human HEK 293 STF cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50094484(CHEMBL2323033 | CHEBI:3556 | US9284299, CGP049090 ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta-Catenin/GST-tagged TCF4 protein-protein interaction in human HCT-116 cells incubated for 24 hrs by immunoprecipitation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619759(CHEMBL5397220)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta-Catenin/GST-tagged TCF4 protein-protein interaction in human HCT-116 cells incubated for 24 hrs by immunoprecipitation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50500850(CHEMBL261214)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of beta-Catenin/GST-tagged TCF4 protein-protein interaction in human HCT-116 cells incubated for 24 hrs by immunoprecipitation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50589362(CHEMBL5181203)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of His-tagged beta-Catenin (134 to 668 residues)/GST-tagged N-terminal TCF4 (1 to 55 residues) (unknown origin) protein-protein interactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619754(CHEMBL5410214)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of wild type beta-Catenin/TCF4 protein-protein interaction in human Hep3B cells incubated for 24 hrs by TOPFLASH reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014148(CHEMBL3260853)
Affinity DataKi:  1.36E+3nMAssay Description:Inhibition of wild type beta-Catenin (142 to 686 residues) (unknown origin)/C-terminal fluorescein-labeled human TCF4 (7 to 51 residues) protein-prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619761(CHEMBL4115972)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of His6-tagged human beta-Catenin (138 to 686 residues)/biotinylated human BCL9 (350 to 375 residues) protein-protein interaction assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.14E+3nMAssay Description:Inhibition of wild type beta-Catenin (142 to 686 residues) (unknown origin)/C-terminal fluorescein-labeled human TCF4 (7 to 51 residues) protein-prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619757(CHEMBL5407683)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of Flag-tagged beta-Catenin (unknown origin)/Flag-tagged BCL9 (unknown origin) protein-protein interaction assessed as inhibition constant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM213763(US9284299, 14)
Affinity DataKi:  7.24E+3nMAssay Description:Inhibition of wild type beta-Catenin (142 to 686 residues) (unknown origin)/C-terminal fluorescein-labeled human TCF4 (7 to 51 residues) protein-prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50094602(CHEMBL3589010 | US9284299, iCRT14 | US9738628, Com...)
Affinity DataKi:  5.35E+4nMAssay Description:Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interaction assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM213749(US9284299, iCRT5 | US9738628, Compound iCRT5)
Affinity DataKi:  8.03E+4nMAssay Description:Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interaction assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50436058(PNU-74654 | CHEMBL254381 | US9738628, Compound PNU...)
Affinity DataKi:  1.81E+5nMAssay Description:Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interaction assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50094606(CHEMBL3589009 | US9284299, iCRT3 | US9738628, Comp...)
Affinity DataKi:  3.65E+5nMAssay Description:Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interaction assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed