Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50015685
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276749(WO2015140658, Example 19.21 | US10188653, Example ...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50588577(CHEMBL5176366)
Affinity DataIC50: 12nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276760(US10071992, Example 6a)
Affinity DataIC50: 29.5nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276760(US10071992, Example 6a)
Affinity DataIC50: 30nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50588576(CHEMBL5207410)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM503720(US11034678, Example 3.6)
Affinity DataIC50: 35nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50588580(CHEMBL5176043)
Affinity DataIC50: 85nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM323589(US10188653, Example 1 | US9789110, 1)
Affinity DataIC50: 92nMAssay Description:Inhibition of DGAT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276754(US10071992, Example 3.3 | N-(1,1-dioxidotetrahydro...)
Affinity DataIC50: 196nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276751((R)-2-(5-((3-Ethoxypyridin-2-yl)oxy)pyridin-3-yl)-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50588578(CHEMBL5171697)
Affinity DataIC50: 353nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50588579(CHEMBL5173066)
Affinity DataIC50: 501nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 833nMAssay Description:Inhibition of rat DGAT2 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into tria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 7.80E+3nMAssay Description:Reversible inhibition of CYP2C9 in pooled human liver microsomes using 4-Hydroxydiclofenac as substrate incubated for 10 mins in presence of NADPH by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 8.70E+3nMAssay Description:Reversible inhibition of CYP2C9 in pooled human liver microsomes using 4-Hydroxydiclofenac as substrate incubated for 10 mins in presence of NADPH by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 2.40E+4nMAssay Description:Reversible inhibition of CYP2B6 in pooled human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in pooled human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Reversible inhibition of CYP2C8 in pooled human liver microsomes using desethylamodiaquine as substrate incubated for 10 mins in presence of NADPH by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Reversible inhibition of CYP2C19 in pooled human liver microsomes using 4-Hydroxymephenytoin as substrate incubated for 20 mins in presence of NADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Reversible inhibition of CYP2D6 in pooled human liver microsomes using dextrorphan as substrate incubated for 14 mins in presence of NADPH by HPLC-MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Reversible inhibition of CYP1A2 in pooled human liver microsomes using acetaminophen as substrate incubated for 20 mins in presence of NADPH by HPLC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Reversible inhibition of CYP1A2 in pooled human liver microsomes using acetaminophen as substrate incubated for 20 mins in presence of NADPH by HPLC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse MGAT1 using [1-14C]decanoyl-CoA and 2-oleoylglycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human MGAT2 using [1-14C]decanoyl-CoA and 1-decanoyl-rac-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse MGAT1 using [1-14C]decanoyl-CoA and 2-oleoylglycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human MGAT3 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human MGAT2 using [1-14C]decanoyl-CoA and 1-decanoyl-rac-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human DGAT1 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human MGAT3 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human DGAT1 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 5.70E+4nMAssay Description:Reversible inhibition of CYP2C19 in pooled human liver microsomes using 4-Hydroxymephenytoin as substrate incubated for 20 mins in presence of NADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP3A4/5 in pooled human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2B6 in pooled human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2C8 in pooled human liver microsomes using desethylamodiaquine as substrate incubated for 10 mins in presence of NADPH by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2D6 in pooled human liver microsomes using dextrorphan as substrate incubated for 14 mins in presence of NADPH by HPLC-MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of hERG by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP1A2 in pooled human liver microsomes using acetaminophen as substrate incubated for 20 mins in presence of NADPH by HPLC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed