Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50018558
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of FGFR2 V564M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human RET V804L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of wild type FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human wild type RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human wild type RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human RET V804M mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of human RET V804L mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of FGFR1 V561M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human RET V804M mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50459416(CHEMBL4216473)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of wild type FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50459416(CHEMBL4216473)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Mouse)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of FGFR4 in mouse BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of wild type FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US9266883, 83 | US11136320, Reference Compound)
Affinity DataIC50: 9nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of KIT T670I mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 27nMAssay Description:Inhibition of wild type KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 45nMAssay Description:Inhibition of RET V804M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of PDGFRalpha D842V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed