Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50018567
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609616(CHEMBL5291353)
Affinity DataIC50: 15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609617(CHEMBL5284387)
Affinity DataIC50: 15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609613(CHEMBL5270000)
Affinity DataIC50: 15nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368373(US10227342, Example 9)
Affinity DataIC50: 19nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368372(US10227342, Example 8)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609607(CHEMBL5281266)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609615(CHEMBL5266834)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368446(US10227342, Example 77)
Affinity DataIC50: 24nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368374(US10227342, Example 10)
Affinity DataIC50: 31nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609609(CHEMBL5275712)
Affinity DataIC50: 32nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609605(CHEMBL5283216)
Affinity DataIC50: 35nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368374(US10227342, Example 10)
Affinity DataIC50: 35nMAssay Description:Inhibition of EGR-induced wild type EGFR phosphorylation in human A-431 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609602(CHEMBL5284255)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609610(CHEMBL5279794)
Affinity DataIC50: 39nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609608(CHEMBL5286091)
Affinity DataIC50: 40nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609606(CHEMBL5279491)
Affinity DataIC50: 42nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368402(US10227342, Example 36)
Affinity DataIC50: 43nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609612(CHEMBL5271640)
Affinity DataIC50: 45nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609614(CHEMBL5271718)
Affinity DataIC50: 49nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368401(US10227342, Example 35)
Affinity DataIC50: 57nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609601(CHEMBL5266482)
Affinity DataIC50: 71nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368447(US10227342, Example 78)
Affinity DataIC50: 79nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368379(US10227342, Example 14)
Affinity DataIC50: 84nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029685(CHEMBL3353404 | US10227342, Example 52)
Affinity DataIC50: 95nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368394(US10227342, Example 28)
Affinity DataIC50: 142nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609611(CHEMBL5276760)
Affinity DataIC50: 147nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609600(CHEMBL5291010)
Affinity DataIC50: 210nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368448(US10227342, Example 79)
Affinity DataIC50: 224nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609603(CHEMBL5266896)
Affinity DataIC50: 288nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50267296(CHEMBL4104658)
Affinity DataIC50: 405nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM149404(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50609604(CHEMBL5286532)
Affinity DataIC50: 2.97E+3nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed